Escudo Universidad de Pamplona

Repositorio Institucional

Universidad de Pamplona

Preservamos, organizamos y difundimos la producción académica, científica, investigativa y cultural de la Universidad de Pamplona, garantizando el acceso abierto al conocimiento generado por nuestra comunidad universitaria.

Explorar colecciones

Por favor, use este identificador para citar o enlazar este ítem: https://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/12262
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorFonseca Beltrán, Carlos Alberto.-
dc.date.accessioned2026-11-06T16:31:55Z-
dc.date.available2025-
dc.date.available2026-11-06T16:31:55Z-
dc.date.issued2025-
dc.identifier.citationFonseca Beltrán, C. A. (2025). Manejo Epidemiologia De Un Brote De La Enfermedad De Glässer Y Su Control Posinfeccion En La Estación Agraria San Pablo [Trabajo de Grado Pregrado, Universidad de Pamplona]. Repositorio Hulago Universidad de Pamplona. https://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/12262es_CO
dc.identifier.urihttps://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/12262-
dc.descriptionSe presentó un brote de la Enfermedad de Glässer (agente causal Glaesserella parasuis) del cual se describe el manejo epidemiológico ocurrido en la Estación Agraria San Pablo, en un sistema de producción de ciclo completo, con animales de la línea genética PIC 337. el objetivo fue identificar las posibles causas que pudieron estar involucrada en el desarrollo del brote y analizar las medidas que se implementaron para su manejo, control y diagnóstico mediante la recopilación y sistematización de datos clínicos, registro sanitarios, necropsia e histopatología. El brote coincidió con la modificación del protocolo de vacunación para Mycoplasma hyorhi y circovirus porcino tipo 2, para los cuales se hizo única aplicación y no la dos como era habitual. Esto llevo a una brecha en el desarrollo inmunitario y dejo puertas abierta a Glaesserella parasuis, Los signos clínicos incluyeron fiebre, hiporexia, anorexia, claudicación y postración. En la necropsia se observó, poliserositis fibrinosa, artritis, esplenomegalia y alteración en otros órganos compatibles con la enfermedad. El tratamiento con antibióticos y AINES, la restauración del protocolo sanitario, el manejo correcto de los procesos de bioseguridad y la aplicación de vacuna contra Glaesserella parasuis, permitieron la estabilización del microambiente del hato y la reducción de la morbilidad. El estudio de los serotipos y los protocolos para su contención fueron de vital importancia para tener una inmunidad colectiva y efectiva. A lo largo de la práctica se logró identificar otros desencadenantes del brote epidemiológico, la exposición prolongada a gases nocivos (amonio cuaternario y otras sustancias químicas) por fallas en el protocolo de aseo y por falta de capacitación al personal y la alteración del plan sanitario en cuanto a la implementación de nuevas vacunas. Lo anteriormente descrito llevó a identificar los problemas de salubridad y vacunación como causales del brote de la enfermedad de Glässer.es_CO
dc.description.abstractAn outbreak of Glässer's disease (caused by Glaesserella parasuis) was reported, and the epidemiological management of this outbreak is described. It occurred at the San Pablo Agricultural Station in a complete production system with animals of the PIC 337 genetic line. The objective was to identify the possible causes involved in the outbreak and to analyze the measures implemented for its management, control, and diagnosis through the collection and systematization of clinical data, health records, necropsy, and histopathology. The outbreak coincided with a modification of the vaccination protocol for Mycoplasma hyorhi and porcine circovirus type 2, for which only one application was given instead of the usual two. This led to a gap in immune development and left the animals vulnerable to Glaesserella parasuis. Clinical signs included fever, hyporexia, anorexia, lameness, and prostration. The necropsy revealed fibrinous polyserositis, arthritis, splenomegaly, and alterations in other organs consistent with the disease. Treatment with antibiotics and NSAIDs, restoration of the sanitary protocol, proper management of biosecurity processes, and administration of the Glaesserella parasuis vaccine allowed for the stabilization of the herd's microenvironment and a reduction in morbidity. The study of serotypes and the protocols for their containment were vital for achieving effective herd immunity. Throughout the practice, other triggers of the epidemiological outbreak were identified, including prolonged exposure to harmful gases (quaternary ammonium compounds and other chemicals) due to failures in the cleaning protocol and a lack of staff training, as well as alterations to the sanitary plan regarding the implementation of new vaccines. The above led to the identification of sanitation and vaccination problems as the causes of the Glässer's disease outbreak.es_CO
dc.format.extent41es_CO
dc.format.mimetypeapplication/pdfes_CO
dc.language.isoeses_CO
dc.publisherUniversidad de Pamplona - Facultad de Ciencias Agrarias.es_CO
dc.subjectBioseguridad.es_CO
dc.subjectBrote.es_CO
dc.subjectEnfermedad de Glässer.es_CO
dc.subjectEpidemiologia.es_CO
dc.subjectGlaesserella parasuis.es_CO
dc.subjectProtocolo sanitario.es_CO
dc.titleManejo Epidemiologia De Un Brote De La Enfermedad De Glässer Y Su Control Posinfeccion En La Estación Agraria San Pablo.es_CO
dc.typehttp://purl.org/coar/resource_type/c_7a1fes_CO
dc.date.accepted2025-
dc.relation.referencesDone, S. H., Paton, D. J., & White, M. E. C. (1996). REVIEW PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS): A REVIEW, WITH EMPHASIS ON PATHOLOGICAL, VIROLOGICAL AND DIAGNOSTIC ASPECTS (Vol. 152).es_CO
dc.relation.referencesDuan, Y., Hao, Y., Feng, H., Shu, J., & He, Y. (2025). Research progress on Haemophilus parasuis vaccines. In Frontiers in Veterinary Science (Vol. 12). Frontiers Media SA. https://doi.org/10.3389/fvets.2025.1492144.es_CO
dc.relation.referencesEspíndola, J. P., Balbinott, N., Gressler, L. T., Machado, G., Klein, C. S., Rebelatto, R., Martín, C. B. G., Kreutz, L. C., Schryvers, A. B., & Frandoloso, R. (2019). Molecular serotyping of clinical strains of Haemophilus (Glaesserella) parasuis brings new insights regarding Glässer’s disease outbreaks in Brazil. PeerJ, 2019(5). https://doi.org/10.7717/peerj.6817.es_CO
dc.relation.referencesFeng, Y., Zhang, H., Wu, Z., Wang, S., Cao, M., Hu, D., & Wang, C. (2014). Streptococcus suis infection: An emerging/reemerging challenge of bacterial infectious diseases? In Virulence (Vol. 5, Issue 4, pp. 477–497). Taylor and Francis Inc. https://doi.org/10.4161/viru.28595.es_CO
dc.relation.referencesFiers, J., Cay, A. B., Maes, D., & Tignon, M. (2024). A Comprehensive Review on Porcine Reproductive and Respiratory Syndrome Virus with Emphasis on Immunity. In Vaccines (Vol. 12, Issue 8). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/vaccines12080942.es_CO
dc.relation.referencesFu, S., Yin, R., Zuo, S., Liu, J., Zhang, Y., Guo, L., Qiu, Y., Ye, C., Liu, Y., Wu, Z., Hou, Y., & Hu, C. A. A. (2020). The effects of baicalin on piglets challenged with Glaesserella parasuis. Veterinary Research, 51(1). https://doi.org/10.1186/s13567-020-00826-5.es_CO
dc.relation.referencesGonzález-Fernández, A., Mencía-Ares, O., García-Iglesias, M. J., Petrocchi-Rilo, M., Miguélez-Pérez, R., Gutiérrez-Martín, C. B., & Martínez-Martínez, S. (2024). Virulence and Antimicrobial Resistance Characterization of Glaesserella parasuis Isolates Recovered from Spanish Swine Farms. Antibiotics, 13(8). https://doi.org/10.3390/antibiotics13080741.es_CO
dc.relation.referencesGonzález-Fernández. (2024). TbpB-based oral mucosal vaccine provides heterologous protection against Glässer’s disease caused by different serovars of Spanish field isolates of Glaesserella parasuis. Porcine Health Management, 10(1). https://doi.org/10.1186/s40813-024-00404-7.es_CO
dc.relation.referencesHattab, J., Marruchella, G., Trachtman, A. R., Gabrielli, L., Bernabò, N., Mosca, F., & Tiscar, P. G. (2022). Effect of Vaccination against Glässer’s Disease in a Farm Suffering from Polyserositis in Weaned Pigs. Veterinary Sciences, 9(12). https://doi.org/10.3390/vetsci9120691.es_CO
dc.relation.referencesLin, W. H., Liou, Z. W., Lin, S. M., Yang, C. Y., Lin, C. F., Chang, Y. F., Lin, C. N., & Chiou, M. T. (2025). Comparison of antimicrobial susceptibility of Glaesserella parasuis from different pig production systems in Taiwan between 2015 and 2020. Porcine Health Management, 11(1). https://doi.org/10.1186/s40813-025-00427-8.es_CO
dc.relation.referencesMacedo, N., Gottschalk, M., Strutzberg-Minder, K., Van, C. N., Zhang, L., Zou, G., Zhou, R., Marostica, T., Clavijo, M. J., Tucker, A., & Aragon, V. (2021). Molecular characterization of Glaesserella parasuis strains isolated from North America, Europe and Asia by serotyping PCR and LS-PCR. Veterinary Research, 52(1). https://doi.org/10.1186/s13567-021-00935-9.es_CO
dc.relation.referencesMugabi, R., Silva, A. P. S. P., Hu, X., Gottschalk, M., Aragon, V., Macedo, N. R., Sahin, O., Harms, P., Main, R., Tucker, A. W., Li, G., & Clavijo, M. J. (2023). Molecular characterization of Glaesserella parasuis strains circulating in North American swine production systems. BMC Veterinary Research, 19(1). https://doi.org/10.1186/s12917-023-03698-x.es_CO
dc.relation.referencesPan, S., He, H., An, T. Q., & Wang, S. (2025). Streptococcus suis: A Review of Its Effects on Immune Organs. In Microorganisms (Vol. 13, Issue 7). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/microorganisms13071613.es_CO
dc.relation.referencesPrigol, S. R., Klein, R., Chaudhuri, S., Frandoloso, G. P., Guizzo, J. A., Martín, C. B. G., Schryvers, A. B., Kreutz, L. C., & Frandoloso, R. (2022). TbpBY167A-Based Vaccine Can Protect Pigs against Glässer’s Disease Triggered by Glaesserella parasuis SV7 Expressing TbpB Cluster I. Pathogens, 11(7). https://doi.org/10.3390/pathogens11070766.es_CO
dc.relation.referencesSchuwerk, L., Hoeltig, D., Waldmann, K. H., Strutzberg-Minder, K., Valentin-Weigand, P., & Rohde, J. (2020). Serotyping and pathotyping of Glaesserella parasuis isolated 2012–2019 in Germany comparing different PCR-based methods. Veterinary Research, 51(1). https://doi.org/10.1186/s13567-020-00862-1.es_CO
dc.relation.referencesSilva, A. P. S. P., Almeida, M., Michael, A., Rahe, M. C., Siepker, C., Magstadt, D. R., Piñeyro, P., Arruda, B. L., Macedo, N. R., Sahin, O., Gauger, P. C., Krueger, K. M., Mugabi, R., Streauslin, J. S., Trevisan, G., Linhares, D. C. L., Silva, G. S., Fano, E., Main, R. G., … Clavijo, M. J. (2023). Detection and disease diagnosis trends (2017–2022) for Streptococcus suis, Glaesserella parasuis, Mycoplasma hyorhinis, Actinobacillus suis and Mycoplasma hyosynoviae at Iowa State University Veterinary Diagnostic Laboratory. BMC Veterinary Research, 19(1). https://doi.org/10.1186/s12917-023-03807-w hyosynoviae at Iowa State University Veterinary Diagnostic Laboratory. BMC Veterinary Research, 19(1). https://doi.org/10.1186/s12917-023-03807-w.es_CO
dc.relation.referencesSilva, Moreno, L. Z., Matajira, C. E. C., Silva, A. P. S., Araújo, K. M., Gomes, V. T. M., Barbosa, M. R. F., Sato, M. I. Z., & Moreno, A. M. (2022). Serotyping and Antimicrobial Susceptibility Profiling of Glaesserella parasuis Isolated from Diseased Swine in Brazil. Pathogens, 11(12). https://doi.org/10.3390/pathogens11121443.es_CO
dc.relation.referencesTassis, P. D., Tsakmakidis, I., Papatsiros, V. G., Koulialis, D., Nell, T., Brellou, G., & Tzika, E. D. (2017). A randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (Mycoplasma hyopneumoniae) and porcine Circovirus type 2 (PCV2) in the presence of strong maternally derived PCV2 immunity in pigs. BMC Veterinary Research, 13(1). https://doi.org/10.1186/s12917-017-1014-7.es_CO
dc.relation.referencesWang, Q., Chang, X., Liu, M., Lu, Q., Zhu, M., Lin, H., & Fan, H. (2021). Glaesserella parasuis serotype 4 HPS4-YC disrupts the integrity of the swine tracheal epithelial barrier and facilitates bacterial translocation. Veterinary Research, 52(1), 135. https://doi.org/10.1186/s13567-021-01005-w.es_CO
dc.relation.referencesWanjiru Maingi, J., Xiong, Q., Wei, Y., Ma, Q., Wang, J., Liu, M., Feng, Z., Bai, F., Bao, E., & Shao, G. (2014). Detection, Isolation and Identification of M. hyorhinis Isolates and Comparison of their Antimicrobial Susceptibility, Immunogenicity and Virulence (Vol. 2, Issue 1).es_CO
dc.relation.referencesWu, C. F., Hsu, C. Y., Chou, C. C., Wang, C. M., Huang, S. W., & Kuo, H. C. (2023). Serotypes, virulence factors and multilocus sequence typing of Glaesserella parasuis from diseased pigs in Taiwan. PeerJ, 11. https://doi.org/10.7717/peerj.15823.es_CO
dc.relation.referencesYang, F., Yang, L., Duan, X., Qian, Y., Ma, H., Jia, X., Huo, X., Dong, W., Chen, H., & Tan, C. (2025). Isolation and identification of Mycoplasma hyorhinis and virulence evaluation of its field isolates. Frontiers in Veterinary Science, 12. https://doi.org/10.3389/fvets.2025.1542992.es_CO
dc.relation.referencesYang, Zhang, Y., Zhao, Q., Du, S., Huang, X., Wu, R., Yan, Q., Han, X., Wen, Y., & Cao, S. J. (2024). HbpA from Glaesserella parasuis induces an inflammatory response in 3D4/21 cells by activating the MAPK and NF-κB signalling pathways and protects mice against G. parasuis when used as an immunogen. Veterinary Research, 55(1), 93. https://doi.org/10.1186/s13567-024-01344-4.es_CO
dc.relation.referencesZhang, P., Li, C., Shang, S., Huang, T., Liu, J., Ge, Q., Liao, X., Fang, L., & Yu, Y. (2025). Antimicrobial Susceptibility of Glaesserella parasuis to Macrolides and Characterization of erm(T)-Carrying Mobile Elements on Chromosome. Animals, 15(2). https://doi.org/10.3390/ani15020164.es_CO
dc.relation.referencesZhao, G., Ying, L., Shi, Y., Dong, Y., Fu, M., & Shen, Z. (2024). Potential mechanisms of Streptococcus suis virulence-related factors in blood–brain barrier disruption. One Health Advances, 2(1). https://doi.org/10.1186/s44280-024-00059-7.es_CO
dc.relation.referencesZhu, K., Yu, D., An, J., & Li, Y. (2021). Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis. Veterinary Research, 52(1), 100. https://doi.org/10.1186/s13567-021-00967-1.es_CO
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2es_CO
dc.type.coarversionhttp://purl.org/coar/resource_type/c_2df8fbb1es_CO
Aparece en las colecciones: Medicina Veterinaria

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Fonseca_2025_TG.pdfFonseca_2025_TG936,78 kBAdobe PDFVisualizar/Abrir


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.