Reporte de caso. Hipercortisolismo en canino hembra de 7 años raza Beagle.

Abstract

Hypercortisolism or Cushing's Syndrome is an endocrine disease of the adrenal gland that consists of an excessive production of cortisol. This report describes the clinical case of hypercortisolism of a canine at the Clínica Protectora de Animales in the city of Bogota, Colombia. On february 24, 2023, a female canine, Beagle breed, 7 years old, spayed, with a history of convulsions, cystitis, stomach problems, polydipsia, polyuria, overweight, was admitted for consultation. Clinical examination revealed a heart rate of 120 BPM, respiratory rate 30 RPM, temperature of 38.4°C, non-reactive lymph nodes, body condition 5/5, capillary refill time of 2", skin fold return 2", strong, symmetrical, and concordant pulse. On palpation, umbilical hernia and mild pain in the epigastric region were observed. The diagnostic plan consisted of laboratory tests such as blood count, ALT, triglycerides, cholesterol, creatinine; the blood count showed erythrocytosis, codocytes, rouleaux and neutrophils. Blood chemistry showed an increase in the enzyme Alanine Aminotransferase (ALT) and hypertriglyceridemia. Subsequently, a low dose dexamethasone suppression test was performed to evaluate basal serum cortisol, cortisol after 4 hours of dexamethasone administration and finally cortisol after 8 hours prior to dexamethasone administration. Finally, abdominal ultrasound was performed and bilateral enlargement of the adrenal glands, enlargement of the liver and presence of sediment in the gallbladder were observed. Treatment was trilostane at a dose of 2mg/kg orally every 24 hours, Biopets Renal® and ursodeoxycholic acid at a dose of 10mg/kg orally every 24 hours.