Efecto de la bursectomía sobre la repuesta inmune (humoral) frente a la enfermedad de Newcastle.

Abstract

In the production of broilers, the health of the flock has an essential aspect, in the search to obtain meat in the shortest possible time; bursa of Fabricius (BF) is the lymphoid organ responsible for the differentiation of B lymphocytes, the injury to this organ represents the optimal performance or not of the batch. In order to assess the humoral immune response against the Newcastle vaccine (ND), a total bursectomy of bursa of Fabricius (B) was performed and the serological profiles were compared using the hemagglutination [HI] inhibition technique with chickens. not bursectomized. Thus, chickens from the ROSS AP line were distributed in 5 treatments: T0 = chickens without vaccine and BF; T1 = chickens B on day 21 and vaccinated on day 22; T2 = chickens BF and vaccinated on day 22; T3 = chickens B on day 28 and vaccinated on day 29; T4 = chickens BF and vaccinated on day 29. The sera were obtained by centrifugation in the Biomedical Sciences laboratory of the University of Pamplona, and sent to a commercial laboratory (SERVET S.A.S) for the HI test (8 Hemagglutinating Units [AHU]). When analyzing the results obtained, the antibody titers for Newcastle disease, there were no significant differences between the different treatments, between the bursectomized birds and the controls, taking into account that the birds bursectomized on days 21 and 28 (T1 and T3), generated seroconversion by the HI test at 35, 42 and 49 days, respectively. We can conclude that removing bursa of Fabricius from day 21 does not compromise the humoral immune response for Newcastle disease. This finding is explained by the function of bursa of Fabricius as a maturing organ for B lymphocytes, which when mature begin to migrate from bursa of Fabricius to secondary lymphoid organs such as the spleen and to all lymphoid aggregates distributed in the body.