Linfoma linfoblástico difuso multicéntrico de alto grado en un canino.

Abstract

The clinical case of a canine with high-grade multicentric diffuse lymphoblastic lymphoma is presented, diagnosed through physical examination, hematological, cytological and histopathological and ultrasonographic studies carried out at the Veterinary Clinic of Small Animals MascoVet, Cúcuta - Colombia. The patient was admitted due to enlargement and pain on palpation in the submandibular, scapular region and caudal level of the posterior limbs compatible with the location of the lymph nodes. He underwent clinical examination, hematological, blood biochemistry, ultrasonography, cytology and histopathology. The most relevant findings were submandibular lymphadenomegaly, pre-scapular, superficial popliteal and bilateral middle iliac, splenomegaly, by palpation and ultrasonography. Bicitopenia due to leukopenia (neutrophilia and lymphopenia) and thrombocytopenia, hypoproteinemia by hematology. Lymphoma by cytology. By histopathology, malignant tumor of Round cells: high- grade diffuse lymphoblastic lymphoma. It was treated with the 19-week CHOP protocol from the University of Wisconsin-Madison for dogs. The patient presented a complete response of the first week of CHOP and remained stable until the fourth week, where after the application of Doxorubicin and low in the dose of Prednisolone the patient was destabilized, manifesting frequent vomiting and decay, signs that led to the owner to desist from chemotherapy.