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  • Facultad de Ciencias Básicas
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    dc.contributor.authorGarzón González, Harold Duvan.-
    dc.date.accessioned2023-02-17T15:38:31Z-
    dc.date.available2019-11-01-
    dc.date.available2023-02-17T15:38:31Z-
    dc.date.issued2020-
    dc.identifier.citationGarzón González, H. D. (2019). Efecto citotóxico del deoxinivalenol sobre células humanas y su presencia en el arroz cultivado en Cúcuta y el Zulia [Trabajo de Grado Pregrado, Universidad de Pamplona]. Repositorio Hulago Universidad de Pamplona. http://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/5940es_CO
    dc.identifier.urihttp://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/5940-
    dc.descriptionEn la actualidad, la frecuente contaminación con deoxinivalenol (DON) en los granos de cereales y sus subproductos, se ha convertido en un problema importante en la industria alimentaria y en la salud pública a nivel mundial. Por ende, en el presente estudio, se estableció la presencia de hongos micotoxigénicos y de DON en el arroz cultivado en los municipios de Cúcuta y El Zulia. La incidencia de los hongos micotoxigénicos en el arroz cultivado se evaluó por medio de siembras en agar PDA y la presencia de DON con la técnica de cromatografía líquida de alta resolución (HPLC). Sumado a esto, se evaluó el efecto citotóxico de DON en la línea celular HepG2 y en células polimorfonucleares (PMN), mediante los parámetros de viabilidad celular (MTT), cambios morfológicos (Microscopía Electrónica de Transmisión) y tipo de muerte celular (Citometría de Flujo). Se evidenció la presencia de hongos micotoxigénicos del género Aspergillus spp., Penicillium spp. y Fusarium spp., siendo éste último el de mayor ocurrencia en las muestras de arroz cultivado en los municipios mencionados. Por el contrario, no se presentaron valores detectables de DON en las muestras de arroz. El efecto citotóxico de DON en las células HepG2, se presentó de manera dependiente de la concentración y tiempo de exposición, con una CI50 de 42,82 µM±1,2 y 29,6 µM±4,8 a 48 y 72 h., respectivamente. Se observaron cambios morfológicos en las células HepG2, como fragmentación del contenido celular y nuclear, formación de protuberacias en la membrana plasmática, cuerpos apoptóticos, así como alteraciones de la morfología celular y por tanto pérdida de los contactos célula a célula. Finalmente, se detectaron cambios bioquímicos como la externalización de las fosfatidilserina y la fragmentación del DNA por citometría de flujo en las células PMN, que determinaron la apoptosis en hasta el 52,74 % ±1,3 de la población celular. Los resultados sugieren que el arroz en cultivo presenta las condiciones óptimas para el crecimiento de hongos toxigénicos Como Fusarium spp., pero no para la producción del DON. Por otro lado, indican que la exposición al DON sobre las células HepG2 y PMN resulta en la muerte celular apoptótica.es_CO
    dc.description.abstractEl autor no proporciona la información sobre este ítem.es_CO
    dc.format.extent110es_CO
    dc.format.mimetypeapplication/pdfes_CO
    dc.language.isoeses_CO
    dc.publisherUniversidad de Pamplona – Facultad de Ciencias Básicas.es_CO
    dc.subjectApoptosis.es_CO
    dc.subjectArroz cultivado.es_CO
    dc.subjectCitotoxicidad.es_CO
    dc.subjectDeoxinivalenol.es_CO
    dc.subjectFusarium spp.es_CO
    dc.titleEfecto citotóxico del deoxinivalenol sobre células humanas y su presencia en el arroz cultivado en Cúcuta y el Zulia.es_CO
    dc.typehttp://purl.org/coar/resource_type/c_7a1fes_CO
    dc.date.accepted2019-08-01-
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