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  1. Repositorio Institucional Universidad de Pamplona
  2. Tesis de maestría y doctorado
  3. Facultad de Ciencias Básicas
  4. Maestría en Biología Molecular y Biotecnología
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dc.contributor.authorParada Botia, Mayra Yurley.-
dc.date.accessioned2025-04-24T18:24:07Z-
dc.date.available2022-
dc.date.available2025-04-24T18:24:07Z-
dc.date.issued2022-
dc.identifier.citationParada Botia, M. Y. (2022). Efecto Apoptótico y/o Necrótico de Zearalenona en células humanas y su cuantificación en el arroz cultivado en Norte de Santander [Trabajo de Grado Maestría, Universidad de Pamplona]. Repositorio Hulago Universidad de Pamplona. http://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/9435es_CO
dc.identifier.urihttp://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/9435-
dc.descriptionLas micotoxinas son metabolitos secundarios, sintetizados por diferentes especies de hongos filamentosos, siendo los géneros Fusarium, Aspergillus y Penicillium, los contaminantes micotoxigénicos más relevantes. Se encuentran frecuentemente como contaminantes naturales en una amplia variedad de alimentos (leche, frutos secos, granos, cereales y derivados) y piensos, representando un riesgo para la salud humana y animal. Por lo tanto, en el presente estudio se cuantificó y se estableció la presencia de ZEA en 3 muestras de arroz de cultivo (M009: 98 µg/Kg, M010:167 µg/Kg y M011: 490 µg/Kg) de 4 municipios de Norte de Santander por cromatografía líquida de alta eficacia (HPLC); a su vez, se pudo establecer la presencia de Fusarium sp., presuntivamente, teniendo en cuenta la caracterización fenotípica de acuerdo a la morfología macroscópica, microscópica y crecimiento micelial, en tres medios de cultivo (PDA, Avena, DG18). Adicionalmente, se evaluó el efecto citotóxico de un patrón de ZEA (10 µg/ml), mediante el ensayo de viabilidad (MTT), y la inducción de cambios morfológicos por microscopia electrónica de trasmisión (MET) en la línea celular HepG2. Los resultados obtenidos indicaron, que ZEA causó una disminución de la actividad metabólica, una reducción significativa en los porcentajes de proliferación celular (p<0,0001), de manera dependiente de la concentración y el tiempo de exposición; y la inducción de cambios morfológicos característicos de la muerte celular por apoptosis. Por citometría de flujo se evaluaron los cambios bioquímicos como externalización de la fosfatidilserina, fragmentación del ADN y pérdida del potencial de membrana mitocondrial, en células polimorfonucleares (PMN). Los resultados indicaron que ZEA, desencadena una serie de eventos de muerte celular, característicos del proceso apoptótico.es_CO
dc.description.abstractMycotoxins are secondary metabolites, synthesized by different species of filamentous fungi, the genera Fusarium, Aspergillus and Penicillium, are the most relevant mycotoxigenic contaminants. They are frequently found as natural contaminants in a wide variety of foods (milk, nuts, grains, cereals and derivatives) and feed, representing a risk to human and animal health. Therefore, in the present study, the presence of ZEA was quantified and established in 3 cultivated rice samples (M009: 98 µg/Kg, M010: 167 µg/Kg and M011: 490 µg/Kg) from 4 municipalities of Norte de Santander by high performance liquid chromatography (HPLC); in turn, the presence of Fusarium sp. could be established, presumptively, taking into account the phenotypic characterization according to macroscopic and microscopic morphology and mycelial growth, in three culture media (PDA, Oatmeal Agar, DG18). Additionally, the cytotoxic effect of a ZEA pattern (10 µg/ml) was evaluated by means of the viability assay (MTT), and the induction of morphological changes by transmission electron microscopy (TEM) in the HepG2 cell line. The results obtained indicated that ZEA caused a decrease in metabolic activity, a significant reduction in the percentages of cell proliferation (p<0.0001), depending on the concentration and exposure time; and the induction of morphological changes characteristic of cell death by apoptosis. Biochemical changes such as externalization of phosphatidylserine, DNA fragmentation and loss of mitochondrial membrane potential in polymorphonuclear cells (PMN) were evaluated by flow cytometry. The results indicated that ZEA triggers a series of cell death events, characteristic of the apoptotic process.es_CO
dc.format.extent140es_CO
dc.format.mimetypeapplication/pdfes_CO
dc.language.isoeses_CO
dc.publisherUniversidad de Pamplona – Facultad de Ciencias Básicas.es_CO
dc.subjectArroz.es_CO
dc.subjectCitotoxicidad.es_CO
dc.subjectFusarium.es_CO
dc.subjectMuerte celular.es_CO
dc.subjectZearalenona.es_CO
dc.titleEfecto Apoptótico y/o Necrótico de Zearalenona en células humanas y su cuantificación en el arroz cultivado en Norte de Santander.es_CO
dc.typehttp://purl.org/coar/resource_type/c_bdcces_CO
dc.date.accepted2022-
dc.relation.referencesbbas, HK; Cartwright, RD; Xie, W; Mirocha, CJ; Richard, JL; Dvorak, TJ; Sciumbato, GL y Shier, WT. (1999). Mycotoxin production by Fusarium proliferatum isolates from rice with Fusarium sheath rot disease. Mycopathologia, 147(2): 97-104. https://doi.org/1 0.1023/a:1007147813326.es_CO
dc.relation.referencesAbbas, S; Murtaza, S; Aslam, F; Khawar, A; Rafique, S y Naheed, S. (2011). Effect of Processing on Nutritional Value of Rice (Oryza sativa). World J. Med. Sci., 6.es_CO
dc.relation.referencesAbbès, S; Ouanes, Z; Salah-Abbès, JB; Abdel-Wahhab, MA; Oueslati, R y Bacha, H. (2007). Preventive role of aluminosilicate clay against induction of micronuclei and chromosome aberrations in bone-marrow cells of Balb/c mice treated with Zearalenone. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 631(2), 85-92. https://doi.org/10.1016/j.mrgentox.2007.01.012.es_CO
dc.relation.referencesAbid-Essefi, S; Baudrimont, I; Hassen, W; Ouanes, Z; Mobio, TA; Anane, R; Creppy, EE y Bacha, H. (2003). DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: Prevention by Vitamin E. Toxicology, 192(2-3), 237-248. https://doi.org/10.1016/s0300-483x(03)00329-9.es_CO
dc.relation.referencesAbid-Essefi, S; Ouanes, Z; Hassen, W; Baudrimont, I, Creppy, E y Bacha, H. (2004). Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone. Toxicology in Vitro, 18(4). pp. 467-474. https://doi.org/10.1016/j.tiv.2003.12.011.es_CO
dc.relation.referencesAbrunhosa, L; Morales, H; Soares, C; Calado, T; Vila-Chã, AS; Pereira, M y Venâncio, A. (2016). A Review of Mycotoxins in Food and Feed Products in Portugal and Estimation of Probable Daily Intakes. Critical Reviews in Food Science and Nutrition, 56(2), 249-265. https://doi.org/10.1080/10408398.2012.720619.es_CO
dc.relation.referencesAdibnia, E; Razi, M y Malekinejad, H. (2016). Zearalenone and 17 β-estradiol induced damages in male rats reproduction potential; evidence for ERα and ERβ receptors expression and steroidogenesis. Toxicon: Official Journal of the International Society on Toxinology, 120, 133-146. https://doi.org/10.1016/j.toxicon.2016.08.009.es_CO
dc.relation.referencesAlbores, LC; Baños, SB; Herrera, JM; Necha, LB; López, MH y Hernández, AC. (2014). Morphological and molecular characterization of pathogenic isolates of Fusarium spp. Obtained from gladiolus corms and their sensitivity to Jatropha curcas L. oil. African Journal of Microbiology Research, 8(8), 724-733. https://doi.org/10.5897/AJMR2013.6413.es_CO
dc.relation.referencesAlcaldía Municipal de San José de Cúcuta. (8 de diciembre de 2017). Nuestro municipio. http://www.cucuta-nortedesantander.gov.co/municipio/nuestro-municipio.es_CO
dc.relation.referencesAlcaldía municipal de El Zulia. (16 de mayo de 2018) Nuestro municipio. http://www.elzulianortedesantander.gov.co/municipio/nuestro-municipio.es_CO
dc.relation.referencesAlcaldía de Puerto Santander. (26 de junio de 2018). Nuestro municipio. http://www.puertosantander-nortedesantander.gov.co/municipio/nuestro-municipio.es_CO
dc.relation.referencesHong, M., Li, J., Li, S., y M. Almutairi, M. (2019). Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation. Cells, 8(11), 1466. https://doi.org/10.3390/cells8111466.es_CO
dc.relation.referencesHongmei, Z. (2012). Extrinsic and Intrinsic Apoptosis Signal Pathway Review. En Apoptosis and medicine. Capitulo I. https://doi.org/10.5772/50129.es_CO
dc.relation.referencesHoward Shapiro M.. (2003). Parameters and Probes. En Practical Flow Cytometry (pp. 273-410). John Wiley & Sons, Ltd. https://doi.org/10.1002/0471 722731.ch7.es_CO
dc.relation.referencesHsu, H; Xiong, J y Goeddel, DV. (1995). The TNF receptor 1 -associated protein TRADD signals cell death and NF-κB activation. Cell, 81(4), 495-504. https://doi.org/10.1016/0092- 8674(95)90070-5.es_CO
dc.relation.referencesHu, J; Xu, M; Dai, Y; Ding, X; Xiao, C; Ji, H y Xu, Y. (2016). Exploration of Bcl-2 family and caspases-dependent apoptotic signaling pathway in Zearalenone-treated mouse endometrial stromal cells. Biochemical and Biophysical Research Communications, 476(4), 553-559. https://doi.org/10.1016/j.bbrc.201 6.05.161.es_CO
dc.relation.referencesHu, H; Tian, M; Ding, C y Yu, S. (2019). The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection. Frontiers in Immunology, 9. https://www.frontiersin.org/articles/10.3389/fimmu.2018.03083.es_CO
dc.relation.referencesIARC (2012). Fungi Producing Significant Mycotoxins; IARC Scientific Publications, 158, 1-30. https://pubmed.ncbi.nlm.nih.gov/23477193/.es_CO
dc.relation.referencesIbáñez-Vea, M; Martínez, R; González-Peñas, E; Lizarraga, E y López de Cerain, A. (2011). Cooccurrence of aflatoxins, ochratoxin A and zearalenone in breakfast cereals from spanish market. Food Control, 22(12), 1949-1955. https://doi.org/10.1016/j.foodcont.2011.05.008.es_CO
dc.relation.referencesIgney, FH y Krammer, PH. (2002). Death and anti-death: Tumour resistance to apoptosis. Nature Reviews Cancer, 2(4), 277-288. https://doi.org/10.1038/nrc776.es_CO
dc.relation.referencesIqbal, SZ; Nisar, S; Asi, MR y Jinap, S. (2014). Natural incidence of aflatoxins, ochratoxin A and zearalenone in chicken meat and eggs. Food Control, 43, pp. 98-103. https://doi.org/10.1016/j.foodcont.2014.02.046.es_CO
dc.relation.referencesAldana, A. (2001). Enciclopedia agropecuaria. Producción Agrícola. 2 ed. Bogotá D. C.: Terranova. p. 304-306.es_CO
dc.relation.referencesIurlaro, R y Muñoz-Pinedo, C. (2016). Cell death induced by endoplasmic reticulum stress. The FEBS Journal, 283(14), 2640-2652. https://doi.org/10.1111/febs.13598.es_CO
dc.relation.referencesJaimes, N; Salmen, S; Colmenares, MC; Burgos, AE; Tamayo, L; Mendoza, RV y Cantor, A. (2016). Cytotoxic effect of palladium (II) inclusion compounds in beta-cyclodextrin. Biomédica, 36(4), 603. https://doi.org/10.7705/biomedica.v36i4.2880.es_CO
dc.relation.referencesJee, Y; Noh, EM; Cho, ES y Son, HY. (2010). Involvement of the Fas and Fas ligand in testicular germ cell apoptosis by zearalenone in rat. Journal of Veterinary Science, 11(2), 115-119. https://doi.org/10.4142/jvs.2010.11.2.115.es_CO
dc.relation.referencesJin, H; Yin, S; Song, X; Zhang, E; Fan, L y Hu, H. (2016). P53 activation contributes to patulininduced nephrotoxicity via modulation of reactive oxygen species generation. Scientific Reports, 6(1), 24455. https://doi.org/10.1038/srep24455.es_CO
dc.relation.referencesJin, Z y El-Deiry, WS. (2005). Overview of cell death signaling pathways. Cancer Biology & Therapy, 4(2), 147-171. https://doi.org/10.4161/cbt.4.2.1508.es_CO
dc.relation.referencesJohnstone, RW; Ruefli, AA y Lowe, SW. (2002). Apoptosis: A Link between Cancer Genetics and Chemotherapy. Cell, 108(2), 153-164. https://doi.org/10.1016/S0092-8674(02)00625-6.es_CO
dc.relation.referencesJulian, L y Olson, MF. (2015). Apoptotic membrane dynamics in health and disease. Cell Health and Cytoskeleton, 2015(7), 133-142. https://doi.org/10.2147/CHC.S57893.es_CO
dc.relation.referencesKamiloglu, S; Sari, G; Ozdal, T y Capanoglu, E. (2020). Guidelines for cell viability assays. Food Frontiers, 1(3), 332-349. https://doi.org/10.1002/fft2.44.es_CO
dc.relation.referencesKamp, DW; Liu, G; Cheresh, P; Kim, SJ; Mueller, A; Lam, AP; Trejo, H; Williams, D; Tulasiram, S; Baker, M; Ridge, K; Chandel, NS y Beri, R. (2013). Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response. American Journal of Respiratory Cell and Molecular Biology, 49(6), 892-901. https://doi.org/10.1165/rcmb.2013-0053OC.es_CO
dc.relation.referencesKaraman, EF; Zeybel, M y Ozden, S. (2020). Evaluation of the epigenetic alterations and gene expression levels of HepG2 cells exposed to zearalenone and α-zearalenol. Toxicology Letters, 326, 52-60. https://doi.org/10.1016/j.toxlet.2020.02.015.es_CO
dc.relation.referencesAlshannaq, A y Yu, JH. (2017). Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food. International Journal of Environmental Research and Public Health, 14(6), 632. https://doi.org/10.3390/ijerph14060632.es_CO
dc.relation.referencesKerr, J. FR; Wyllie, AH y Currie, AR. (1972). Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics. British Journal of Cancer, 26(4), 239-257.es_CO
dc.relation.referencesKharayat, BS y Singh, Y. (2018). Chapter 13 - Mycotoxins in Foods: Mycotoxicoses, Detection, and Management. En A. M. Holban y A. M. Grumezescu (Eds.), Microbial Contamination and Food Degradation (pp. 395-421). Academic Press. https://doi.org/10.1016/B978-0- 12-811515-2.00013-5.es_CO
dc.relation.referencesKhodaei, D., Javanmardi, F., y Khaneghah, A. M. (2021). The global overview of the occurrence of mycotoxins in cereals: A three-year survey. Current Opinion in Food Science, 39, 36- 42. https://doi.org/10.1016/j.cofs.2020.12.012.es_CO
dc.relation.referencesKim, JE; Son, H y Lee, YW. (2018). Biosynthetic mechanism and regulation of zearalenone in Fusarium graminearum. JSM Mycotoxins, 68, 1-6. https://doi.org/10.2520/myco.68-1-2.es_CO
dc.relation.referencesKim, YT; Lee, YR; Jin, J; Han, KH; Kim, H; Kim, JC; Lee, T; Yun, SH y Lee, YW. (2005). Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae. Molecular Microbiology, 58(4), 1102-1113. https://doi.org/10.1111/j.1365- 2958.2005.04884.x.es_CO
dc.relation.referencesKischkel, FC; Hellbardt, S; Behrmann, I; Germer, M; Pawlita, M; Krammer, PH y Peter, ME. (1995). Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a deathinducing signaling complex (DISC) with the receptor. The EMBO Journal, 14(22), 5579- 5588. doi https://doi.org/10.1002/j.1460-2075.1995.tb00245.x.es_CO
dc.relation.referencesKiš, M; Vulić, A; Kudumija, N; Šarkanj, B; Jaki Tkalec, V; Aladić, K; Škrivanko, M; Furmeg, S y Pleadin, J. (2021). A Two-Year Occurrence of Fusarium T-2 and HT-2 Toxin in Croatian Cereals Relative of the Regional Weather. Toxins, 13(39), pp. 1 -12. https://doi.org/10.3390/toxins13010039.es_CO
dc.relation.referencesKnutsen, H; Alexander, J; Barregård, L; Bignami, M; Brüschweiler, B; Ceccatelli, S; Cottrill, B; Dinovi, M; Edler, L; Grasl‐Kraupp, B; Hogstrand, C; Hoogenboom, L; Nebbia, C; Petersen, A; Rose, M; Roudot, AC; Schwerdtle, T; Vleminckx, C; Vollmer, G y Oswald, I. (2017). Risks for animal health related to the presence of zearalenone and its modified forms in feed. EFSA Journal, 15. https://doi.org/10.2903/j.efsa.2017.4851.es_CO
dc.relation.referencesKondratskyi, A; Kondratska, K; Skryma, R y Prevarskaya, N. (2015). Ion channels in the regulation of apoptosis. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10, Part B), 2532-2546. https://doi.org/10.1016/j.bbamem.2014.10.030.es_CO
dc.relation.referencesKouadio, JH; Mobio, TA; Baudrimont, I; Moukha, S; Dano, SD y Creppy, EE. (2005). Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology, 213(1-2), 56-65. https://doi.org/10.1016/j.tox.2005.05.010.es_CO
dc.relation.referencesAmarante-Mendes, GP; Finucane, DM; Martin, SJ; Cotter, TG; Salvesen, GS y Green, DR. (1998). Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death & Differentiation, 5(4), 298-306. https://doi.org/10.1038/sj.cdd.4400354.es_CO
dc.relation.referencesKovalsky Paris, MP; Schweiger, W; Hametner, C; Stückler, R; Muehlbauer, GJ; Varga, E; Krska, R; Berthiller, F y Adam, G. (2014). Zearalenone-16-O-glucoside: A new masked mycotoxin. Journal of Agricultural and Food Chemistry, 62(5), 1181 -1189. https://doi.org/10.1021/jf405627d.es_CO
dc.relation.referencesKowalska, K; Habrowska-Górczyńska, DE; Domińska, K y Piastowska-Ciesielska, AW. (2017). The dose-dependent effect of zearalenone on mitochondrial metabolism, plasma membrane permeabilization and cell cycle in human prostate cancer cell lines. Chemosphere, 180, 455-466. https://doi.org/10.1016/j.chemosphere.2017.04.027.es_CO
dc.relation.referencesKowalska, K; Habrowska-Górczyńska, DE; Urbanek, KA; Domińska, K; Sakowicz, A y Piastowska-Ciesielska, AW. (2019). Estrogen receptor β plays a protective role in zearalenone-induced oxidative stress in normal prostate epithelial cells. Ecotoxicology and Environmental Safety, 172, 504-513. https://doi.org/10.1016/j.ecoenv.2019.01.115.es_CO
dc.relation.referencesKroemer, G; Galluzzi, L y Brenner, C. (2007). Mitochondrial membrane permeabilization in cell death. Physiological Reviews, 87(1), 99-163. https://doi.org/10.1152/physrev.00013.2006.es_CO
dc.relation.referencesKroemer, G; El-Deiry, WS; Golstein, P; Peter, ME; Vaux, D; Vandenabeele, P; Zhivotovsky, B; Blagosklonny, MV; Malorni, W; Knight, RA; Piacentini, M; Nagata, S y Melino, G. (2005). Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death. Cell Death & Differentiation, 12(2), 1463-1467. https://doi.org/10.1038/sj.cdd.4401724.es_CO
dc.relation.referencesKroemer, G; Zamzami, N y Susin, SA. (1997). Mitochondrial control of apoptosis. Immunology Today, 18(1), 44-51. https://doi.org/10.1016/S0167-5699(97)80014-X.es_CO
dc.relation.referencesKumar, GV; Kumar, MA y Kumar, GR. (2010). Growth characteristics of Fusarium spp. Causing wilt disease in Psidium guajava L. in India. Journal of Plant Protection Research, 50(4), 452-462. https://doi.org/10.2478/v10045-010-0076-3.es_CO
dc.relation.referencesKunishige, K; Kawate, N; Inaba, T y Tamada, H. (2017). Exposure to Zearalenone During Early Pregnancy Causes Estrogenic Multitoxic Effects in Mice. Reproductive Sciences (Thousand Oaks, Calif.), 24(3), 421-427. https://doi.org/10.1177/1933719116657194.es_CO
dc.relation.referencesKupcsik, L. (2011). Estimation of Cell Number Based on Metabolic Activity: The MTT Reduction Assay. En M. J. Stoddart (Ed.), Mammalian Cell Viability: Methods and Protocols (pp. 13- 19). Humana Press. https://doi.org/10.1007/978-1-61779-108-6_3.es_CO
dc.relation.referencesLangerak, P y Russell, P. (2011). Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1584), 3562-3571. https://doi.org/10.1098/rstb.2011.0070.es_CO
dc.relation.referencesAmirahmadi, M; Shoeibi, S; Rastegar, H; Elmi, M y Mousavi Khaneghah, A. (2018). Simultaneous analysis of mycotoxins in corn flour using LC/MS-MS combined with a modified QuEChERS procedure. Toxin Reviews, 37(3), 187-195. https://doi.org/10.1080/15569543.2017.1354306.es_CO
dc.relation.referencesLecomte, S; Lelong, M; Bourgine, G; Efstathiou, T; Saligaut, C y Pakdel, F. (2017). Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. Toxicology and Applied Pharmacology, 325, 61-70. https://doi.org/10.1016/j.taap.2017.04.005.es_CO
dc.relation.referencesLee, H; Kang, C; Yoo, YS; Hah, DY; Kim, CH; Kim, E y Kim, JS. (2013). Cytotoxicity and the induction of the stress protein Hsp 70 in Chang liver cells in response to zearalenoneinduced oxidative stress. Environmental Toxicology and Pharmacology, 36(2), 732-740. https://doi.org/10.1016/j.etap.2013.06.005.es_CO
dc.relation.referencesLee, HJ; Oh, SY y Jo, I. (2021). Zearalenone Induces Endothelial Cell Apoptosis through Activation of a Cytosolic Ca2+/ERK1/2/p53/Caspase 3 Signaling Pathway. Toxins, 13(3), 187. https://doi.org/10.3390/toxins13030187.es_CO
dc.relation.referencesLee, R; Kim, DW; Lee, WY y Park, HJ. (2022). Zearalenone Induces Apoptosis and Autophagy in a Spermatogonia Cell Line. Toxins, 14(2), 148. https://doi.org/10.3390/toxins14020148.es_CO
dc.relation.referencesLemasters, JJ; Qian, T; He, L; Kim, JS; Elmore, SP; Cascio, WE y Brenner, DA. (2002). Role of Mitochondrial Inner Membrane Permeabilization in Necrotic Cell Death, Apoptosis, and Autophagy. Antioxidants & Redox Signaling, 4(5), 769-781. https://doi.org/10.1089/152308602760598918.es_CO
dc.relation.referencesLeslie, JF y Summerell, BA. (2006). The Fusarium Laboratory Manual. Wiley-Blackwell. http://gen.lib.rus.ec/book/index.php?md5=70f83b94eb30227f954e619e539ba244.es_CO
dc.relation.referencesLin, L; Zhang, J; Wang, P; Wang, Y y Chen, J. (1998). Thin-layer chromatography of mycotoxins and comparison with other chromatographic methods. Journal of Chromatography A, 815(1), 3-20. https://doi.org/10.1016/S0021 -9673(98)00204-0.es_CO
dc.relation.referencesLioi, MB; Santoro, A; Barbieri, R; Salzano, S y Ursini, MV. (2004). Ochratoxin A and zearalenone: A comparative study on genotoxic effects and cell death induced in bovine lymphocytes. Mutation Research, 557(1). pp.19-27. https://doi.org/10.1016/j.mrgentox.2003.09.009.es_CO
dc.relation.referencesLiu, J y Applegate, T. (2020). Zearalenone (ZEN) in Livestock and Poultry: Dose, Toxicokinetics, Toxicity and Estrogenicity. Toxins, 12(6). pp. 377-406. https://doi.org/10.3390/toxins12060377.es_CO
dc.relation.referencesLiu, KH; Sun, XF; Feng, YZ; Cheng, SF; Li, B; Li, YP; Shen, W y Li, L. (2017). The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicology and Applied Pharmacology, 329, 9-17. https://doi.org/10.1016/j.taap.2017.05.024.es_CO
dc.relation.referencesArur, S; Uche, UE; Rezaul, K; Fong, M; Scranton, V; Cowan, AE; Mohler, W y Han, DK. (2003). Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment. Developmental Cell, 4(4), 587-598. https://doi.org/10.1016/S1534-5807(03)00090-X.es_CO
dc.relation.referencesLiu, T; Zhu, W; Yang, X; Chen, L; Yang, R; Hua, Z y Li, G. (2009). Detection of apoptosis based on the interaction between annexin V and phosphatidylserine. Analytical Chemistry, 81(6), 2410-2413. https://doi.org/10.1021/ac801267s.es_CO
dc.relation.referencesLiu, XL; Wu, RY; Sun, XF; Cheng, SF; Zhang, RQ; Zhang, TY; Zhang, XF; Zhao, Y; Shen, W y Li, L. (2018). Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro. International Journal of Biological Sciences, 14(3), 294- 305. https://doi.org/10.7150/ijbs.23898.es_CO
dc.relation.referencesLiu, Y y Nair, MG. (2010). An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Journal of Natural Products, 73(7), 1193-1195. https://doi.org/10.1021/np1000945.es_CO
dc.relation.referencesLocksley, RM; Killeen, N y Lenardo, MJ. (2001). The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology. Cell, 104(4), 487-501. https://doi.org/10.1016/S0092- 8674(01)00237-9.es_CO
dc.relation.referencesLozano-Sánchez, J; Borrás-Linares, I; Sass-Kiss, A y Segura-Carretero, A. (2018). Chapter 13 - Chromatographic Technique: High-Performance Liquid Chromatography (HPLC). En D.- W. Sun (Ed.), Modern Techniques for Food Authentication (Second Edition) (pp. 459-526). Academic Press. https://doi.org/10.1016/B978-0-12-814264-6.00013-X.es_CO
dc.relation.referencesLu, S. C y Huang, HY. (1994). Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes. Biochemical Pharmacology, 47(5), 859-869. https://doi.org/10.1016/0006-2952(94)90486-3.es_CO
dc.relation.referencesMacey, MG. (2007). Principles of Flow Cytometry. En M. G. Macey (Ed.), Flow Cytometry: Principles and Applications (pp. 1-15). Humana Press. https://doi.org/10.1007/978-1- 59745-451-3_1.es_CO
dc.relation.referencesMagan, N; Hope, R; Cairns, V y Aldred, D. (2003). Post-harvest fungal ecology: Impact of fungal growth and mycotoxin accumulation in stored grain. En X. Xu, J. A. Bailey, y B. M. Cooke (Eds.), Epidemiology of Mycotoxin Producing Fungi: Under the aegis of COST Action 835 ‘Agriculturally Important Toxigenic Fungi 1998–2003’, EU project (QLK 1-CT-1998– 01380), pp. 723-730. Springer Netherlands. https://doi.org/10.1007/978-94-017-1452-5_7.es_CO
dc.relation.referencesMajno, G y Joris, I. (1995). Apoptosis, oncosis, and necrosis. An overview of cell death. The American Journal of Pathology, 146(1), 3-15. doi https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1870771/.es_CO
dc.relation.referencesMajtnerová, P y Roušar, T. (2018). An overview of apoptosis assays detecting DNA fragmentation. Molecular Biology Reports, 45(5), 1469-1478. https://doi.org/10.1007/s11033-018-4258-9.es_CO
dc.relation.referencesAshkenazi, A y Dixit, VM. (1998). Death Receptors: Signaling and Modulation. Science, 281(5381), 1305-1308. https://doi.org/10.1126/science.281.5381.1305.es_CO
dc.relation.referencesMakowska, K; Obremski, K; Zielonka, L y Gonkowski, S. (2017). The Influence of Low Doses of Zearalenone and T-2 Toxin on Calcitonin Gene Related Peptide-Like Immunoreactive (CGRP-LI) Neurons in the ENS of the Porcine Descending Colon. Toxins, 9(3), E98. https://doi.org/10.3390/toxins9030098.es_CO
dc.relation.referencesMakun, HA; Gbodi, TA; Akanya, OH; Salako, EA y Ogbadu, GH. (2007). Fungi and some mycotoxins contaminating rice (Oryza Sativa) in Niger State, Nigeria. African Journal of Biotechnology, 6(2), pp. 099-108, Article 2. https://doi.org/10.4314/ajb.v6i2.56106.es_CO
dc.relation.referencesMally, A; Solfrizzo, M y Degen, GH. (2016). Biomonitoring of the mycotoxin Zearalenone: Current state-of-the art and application to human exposure assessment. Archives of Toxicology, 90(6). pp.1281-1292. https://doi.org/10.1007/s00204-016-1704-0.es_CO
dc.relation.referencesManizan, AL; Oplatowska-Stachowiak, M; Piro-Metayer, I; Campbell, K; Koffi-Nevry, R; Elliott, C; Akaki, D; Montet, D y Brabet, C. (2018). Multi-mycotoxin determination in rice, maize and peanut products most consumed in Côte d’Ivoire by UHPLC-MS/MS. Food Control, 87, pp. 22-30. https://doi.org/10.1016/j.foodcont.2017.11.032.es_CO
dc.relation.referencesMarasas, WFO; Nelson, PE y Toussoun, TA. (1984). Toxigenic Fusarium species. Identity and mycotoxicology. Toxigenic Fusarium Species. Identity and Mycotoxicology. https://www.cabdirect.org/cabdirect/abstract/19871323192.es_CO
dc.relation.referencesMarín, S; Ramos, AJ; Cano-Sancho, G y Sanchis, V. (2013). Mycotoxins: Occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 60. pp. 218-237. https://doi.org/10.1016/j.fct.2013.07.047.es_CO
dc.relation.referencesMarín, S; Sanchis, V; Sáenz, R; Ramos, AJ; Vinas, I y Magan, N. (1998). Ecological determinants for germination and growth of some Aspergillus and Penicillium spp. From maize grain. Journal of Applied Microbiology, 84(1), 25-36. https://doi.org/10.1046/j.1365- 2672.1997.00297.x.es_CO
dc.relation.referencesMarnett, LJ. (2000). Oxyradicals and DNA damage. Carcinogenesis, 21(3), 361-370. https://doi.org/10.1093/carcin/21.3.361.es_CO
dc.relation.referencesMarti, GE; Stetler-Stevenson, M; Bleesing, JJ y Fleisher, TA. (2001). Introduction to flow cytometry. Seminars in Hematology, 38(2), 93-99. https://doi.org/10.1016/s0037- 1963(01)90043-5.es_CO
dc.relation.referencesMartinvalet, D; Zhu, P y Lieberman, J. (2005). Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis. Immunity, 22(3), 355-370. https://doi.org/10.1016/j.immuni.2005.02.004.es_CO
dc.relation.referencesAupanun, S; Phuektes, P; Poapolathep, S; Sutjarit, S; Giorgi, M y Poapolathep, A. (2016). Apoptosis and gene expression in Jurkat human T cells and lymphoid tissues of fusarenonX-treated mice. Toxicon, 123, 15-24. https://doi.org/10.1016/j.toxicon.2016.10.012.es_CO
dc.relation.referencesMartucciello, S; Masullo, M; Cerulli, A y Piacente, S. (2020). Natural Products Targeting ER Stress, and the Functional Link to Mitochondria. International Journal of Molecular Sciences, 21(6), 1905. https://doi.org/10.3390/ijms21061905.es_CO
dc.relation.referencesMasson, JJR; Ostrowski, M; Duette, G; Lee, MKS; Murphy, AJ; Crowe, SM y Palmer, CS. (2020). The Multiparametric Analysis of Mitochondrial Dynamics in T Cells from Cryopreserved Peripheral Blood Mononuclear Cells (PBMCs). Methods in Molecular Biology (Clifton, N.J.), 2184, 215-224. https://doi.org/10.1007/978-1-0716-0802-9_15.es_CO
dc.relation.referencesMayr, U; Butsch, A y Schneider, S. (1992). Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts. Toxicology, 74(2), 135- 149. https://doi.org/10.1016/0300-483X(92)90134-Z.es_CO
dc.relation.referencesMcConkey, DJ y Orrenius, S. (1997). The Role of Calcium in the Regulation of Apoptosis. Biochemical and Biophysical Research Communications, 239(2), 357-366. https://doi.org/10.1006/bbrc.1997.7409.es_CO
dc.relation.referencesMcDonnell, DP; Connor, CE; Wijayaratne, A; Chang, CY y Norris, JD. (2002). Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Progress in Hormone Research, 57, 295-316. https://doi.org/10.1210/rp.57.1.295.es_CO
dc.relation.referencesMesnil, M; Crespin, S; Avanzo, JL y Zaidan-Dagli, ML. (2005). Defective gap junctional intercellular communication in the carcinogenic process. Biochimica Et Biophysica Acta, 1719(1-2), 125-145. https://doi.org/10.1016/j.bbamem.2005.11.004.es_CO
dc.relation.referencesMilani, J. (2013). Ecological conditions affecting mycotoxin production in cereals: A review. Veterinární Medicína, 58(8), pp. 405-411. https://doi.org/10.17221/6979-VETMED.es_CO
dc.relation.referencesMinisterio de Salud y Protección Social (MSPS). (2013). Resolución Número 2674 de 2013.es_CO
dc.relation.referencesMilićević, DR; Skrinjar, M y Baltić, T. (2010). Real and perceived risks for mycotoxin contamination in foods and feeds: Challenges for food safety control. Toxins, 2(4), 572- 592. https://doi.org/10.3390/toxins2040572.es_CO
dc.relation.referencesMoretti, A; Logrieco, AF y Susca, A. (2017). Mycotoxins: An Underhand Food Problem. En A. Moretti y A. Susca (Eds.), Mycotoxigenic Fungi: Methods and Protocols (pp. 3-12). Springer. https://doi.org/10.1007/978-1-4939-6707-0_1.es_CO
dc.relation.referencesAyed-Boussema, I; Bouaziz, C; Rjiba, K; Valenti, K; Laporte, F; Bacha, H y Hassen, W. (2008). The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53- dependent mitochondrial signaling pathway. Toxicology in Vitro, 22(7). pp. 1671-1680. https://doi.org/10.1016/j.tiv.2008.06.016.es_CO
dc.relation.referencesMorris, Navarro LF (2011). Determinación de aflatoxinas en muestras de maíz (Zea mays) y arroz (Oryza sativa) para consumo humano en cinco departamentos de la Costa Caribe Colombiana mediante cromatografía de alta eficiencia durante seis meses en 2011. (Trabajo de grado Maestría). Universidad Nacional de Colombia. https://repositorio.unal.edu.co/handle/unal/8318.es_CO
dc.relation.referencesMosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1), 55-63. https://doi.org/10.1016/0022-1759(83)90303-4.es_CO
dc.relation.referencesMoss, MO. (1996). Mycotoxins. Mycological Research, 100(5), 513-523. https://doi.org/10.1016/S0953-7562(96)80001-3.es_CO
dc.relation.referencesMullen, P. (2004). PARP cleavage as a means of assessing apoptosis. Methods in Molecular Medicine, 88, 171-181. https://doi.org/10.1385/1 -59259-406-9:171.es_CO
dc.relation.referencesNacalai, Tesque Inc. (S. F.). Nacalai Tesque, Inc. Recuperado 20 de marzo de 2022, de https://www.nacalai.co.jp/.es_CO
dc.relation.referencesNaeem, A; James, N; Tanvir, M; Marriam, M; Nathaniel, S y Nathaniel, S. (2017). Fluorescence Activated Cell Sorting (FACS): An Advanced Cell Sorting Technique. PSM Biological Research, 2(2), 83-88.es_CO
dc.relation.referencesNeme, K y Mohammed, A. (2017). Mycotoxin occurrence in grains and the role of postharvest management as a mitigation strategies. A review. Food Control, 78, 412-425. https://doi.org/10.1016/j.foodcont.2017.03.012.es_CO
dc.relation.referencesNiles, AL; Moravec, RA y Riss, TL. (2008). Update on in vitro cytotoxicity assays for drug development. Expert Opinion on Drug Discovery, 3(6), 655-669. https://doi.org/10.1517/17460441.3.6.655.es_CO
dc.relation.referencesNorbury, CJ; y Hickson, ID. (2001). Cellular Responses to DNA Damage. Annual Review of Pharmacology and Toxicology, 41(1), 367-401. https://doi.org/10.1146/annurev.pharmtox.41.1.367.es_CO
dc.relation.referencesNorbury, CJ y Zhivotovsky, B. (2004). DNA damage-induced apoptosis. Oncogene, 23(16), 2797- 2808. https://doi.org/10.1038/sj.onc.1207532.es_CO
dc.relation.referencesBanjerdpongchai, R; Kongtawelert, P; Khantamat, O; Srisomsap, C; Chokchaichamnankit, D; Subhasitanont, P y Svasti, J. (2010). Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells. Journal of Hematology & Oncology, 3(1), 50. https://doi.org/10.1186/1756-8722-3-50.es_CO
dc.relation.referencesNutrition Division. (2003). Manual sobre la aplicación del sistema de Análisis de Peligros y de Puntos Críticos de Control (APPCC) en la prevención y control de las micotoxinas: Centro da Capacitación y Referencia FAO/OIEA para el Control de los Alimentos y los Plaguicidas. FAO. https://www.fao.org/publications/card/es/c/7bbcbf7b-2fd4-59c0-8ff8- 698d4bcf9c29/.es_CO
dc.relation.referencesObeng, E. (2020). Apoptosis (programmed cell death) and its signals—A review. Brazilian Journal of Biology, 81, 1133-1143. do: 10.1590/1519-6984.228437.es_CO
dc.relation.referencesO’Brien, MA; Moravec, RA y Riss, TL. (2001). Poly (ADP-ribose) polymerase cleavage monitored in situ in apoptotic cells. BioTechniques, 30(4), 886-891. https://doi.org/10.2144/01304pf01.es_CO
dc.relation.referencesOk, HE; Kim, DM; Kim, D; Chung, SH; Chung, MS; Park, KH y Chun, HS. (2014). Mycobiota and natural occurrence of aflatoxin, deoxynivalenol, nivalenol and zearalenone in rice freshly harvested in South Korea. Food Control, 37, 284-291. https://doi.org/10.1016/j.foodcont.2013.09.020.es_CO
dc.relation.referencesOmotayo, O. P., Omotayo, A. O., Mwanza, M., y Babalola, O. O. (2019). Prevalence of Mycotoxins and Their Consequences on Human Health. Toxicological Research, 35(1), 1- 7. https://doi.org/10.5487/TR.2019.35.1.001.es_CO
dc.relation.referencesOren, M. (2003). Decision making by p53: Life, death and cancer. Cell Death & Differentiation, 10(4), 431-442. https://doi.org/10.1038/sj.cdd.4401183.es_CO
dc.relation.referencesOrrenius, S; Zhivotovsky, B y Nicotera, P. (2003). Regulation of cell death: The calcium– apoptosis link. Nature Reviews Molecular Cell Biology, 4(7), 552-565. https://doi.org/10.1038/nrm1150.es_CO
dc.relation.referencesOsuchowski, MF y Sharma, RP. (2005). Fumonisin B1 Induces Necrotic Cell Death in BV-2 Cells and Murine Cultured Astrocytes and is Antiproliferative in BV-2 Cells While N2A Cells and Primary Cortical Neurons are Resistant. NeuroToxicology, 26(6), 981-992. https://doi.org/10.1016/j.neuro.2005.05.001.es_CO
dc.relation.referencesOuanes, Z; Abid, S; Ayed, I; Anane, R; Mobio, T; Creppy, EE y Bacha, H. (2003). Induction of micronuclei by Zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: Protective effect of Vitamin E. Mutation Research, 538(1-2). pp.63-70. https://doi.org/10.1016/s1383-5718(03)00093-7.es_CO
dc.relation.referencesOuanes-Ben Othmen, Z; Essefi, S y Bacha, H. (2008). Mutagenic and epigenetic mechanisms of zearalenone: Prevention by Vitamin E. World Mycotoxin Journal, 1(3), 369-374. https://doi.org/10.3920/WMJ2008.1036.es_CO
dc.relation.referencespathways cooperate in zearalenone-induced apoptosis of human leukemic cells. Journal of Hematology & Oncology, 3(1), 50. https://doi.org/10.1186/1756-8722-3-50.es_CO
dc.relation.referencesPalacios, Pru¨ EL y Mendoza Bricen˜o, RV. (1972). An unusual relationship between glial cells and neuronal dendrites in olfactory bulbs of Desmodus rotundus. Brain Research, 36(2), 404-408. https://doi.org/10.1016/0006-8993(72)90744-5.es_CO
dc.relation.referencesPark, AR; Son, H; Min, K; Park, J; Goo, JH; Rhee, S; Chae, SK y Lee, YW. (2015). Autoregulation of ZEB2 expression for zearalenone production in Fusarium graminearum. Molecular Microbiology, 97(5), 942-956. https://doi.org/10.1111/mmi.13078.es_CO
dc.relation.referencesPark, JW; Choi, SY; Hwang, HJ y Kim, YB. (2005). Fungal mycoflora and mycotoxins in Korean polished rice destined for humans. International Journal of Food Microbiology, 103(3), 305-314. https://doi.org/10.1016/j.ijfoodmicro.2005.02.001.es_CO
dc.relation.referencesPaterson, RRM y Lima, N. (2010). How will climate change affect mycotoxins in food? Food Research International, 43(7), pp. 1902-1914. https://doi.org/10.1016/j.foodres.2009.07.010.es_CO
dc.relation.referencesPatil, C y Walter, P. (2001). Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals. Current Opinion in Cell Biology, 13(3), 349-355. https://doi.org/10.1016/S0955-0674(00)00219-2.es_CO
dc.relation.referencesPatriarca, A y Fernández, Pinto V. (2017). Prevalence of mycotoxins in foods and decontamination. Current Opinion in Food Science, 14, 50-60. https://doi.org/10.1016/j.cofs.2017.01.011.es_CO
dc.relation.referencesPeng, X; Yu, Z; Liang, N; Chi, X; Li, X; Jiang, M; Fang, J; Cui, H; Lai, W; Zhou, Y y Zhou, S. (2016). The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1. Oncotarget, 7(11), 12222-12234. https://doi.org/10.18632/oncotarget.7731.es_CO
dc.relation.referencesPereira, CMF. (2013). Crosstalk between Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases. ISRN Cell Biology, 2013, e256404. https://doi.org/10.1155/2013/256404.es_CO
dc.relation.referencesPerkowski, J; Plattner, R; Goliński, P; Vesonder, R y Chelkowski, J. (1990). Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7- dideoxynivalenol, and zearalenone in polish wheat. Mycotoxin Research, 6(1), 7-12. https://doi.org/10.1007/BF031921 33.es_CO
dc.relation.referencesPetit, PX; Lecoeur, H; Zorn, E; Dauguet, C; Mignotte, B y Gougeon, ML. (1995). Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. The Journal of Cell Biology, 130(1), 157-167. https://doi.org/10.1083/jcb.130.1.157.es_CO
dc.relation.referencesBen Salah-Abbès, J; Belgacem, H; Ezzdini, K; Abdel-Wahhab, MA y Abbès, S. (2020). Zearalenone nephrotoxicity: DNA fragmentation, apoptotic gene expression and oxidative stress protected by Lactobacillus plantarum MON03. Toxicon: Official Journal of the International Society on Toxinology, 175, 28-35. https://doi.org/10.1016/j.toxicon.2019.12.004.es_CO
dc.relation.referencesPfeiffer, E; Kommer, A; Dempe, JS; Hildebrand, AA y Metzler, M. (2011). Absorption and metabolism of the mycotoxin zearalenone and the growth promotor zeranol in Caco-2 cells in vitro. Molecular Nutrition & Food Research, 55(4), 560-567. https://doi.org/10.1002/mnfr.201000381.es_CO
dc.relation.referencesPistol, GC; Gras, MA; Marin, DE; Israel-Roming, F; Stancu, M y Taranu, I. (2014). Natural feed contaminant zearalenone decreases the expressions of important pro- and antiinflammatory mediators and mitogen-activated protein kinase/NF-κB signalling molecules in pigs. The British Journal of Nutrition, 111(3), 452-464. https://doi.org/10.1017/S0007114513002675.es_CO
dc.relation.referencesPistritto, G; Trisciuoglio, D; Ceci, C; Garufi, A y D’Orazi, G. (2016). Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany NY), 8(4), 603-619. https://doi.org/10.18632/aging.100934.es_CO
dc.relation.referencesPlenchette, S; Filomenko, R; Logette, E; Solier, S; Buron, N; Cathelin, S y Solary, E. (2004). Analyzing markers of apoptosis in vitro. Methods in Molecular Biology (Clifton, N.J.), 281, 313-331. https://doi.org/10.1385/1 -59259-811-0:313.es_CO
dc.relation.referencesPoon, IKH; Lucas, CD; Rossi, AG y Ravichandran, KS. (2014). Apoptotic cell clearance: Basic biology and therapeutic potential. Nature Reviews Immunology, 14(3), 166-180. https://doi.org/10.1038/nri3607.es_CO
dc.relation.referencesPozarowski, P; Grabarek, J y Darzynkiewicz, Z. (2003). Flow Cytometry of Apoptosis. Current Protocols in Cell Biology, 21(1). https://doi.org/10.1002/0471143030.cb1808s21.es_CO
dc.relation.referencesRai, A; Dixit, S; Singh, SP; Gautam, NK; Das, M y Tripathi, A. (2018). Presence of Zearalenone in Cereal Grains and Its Exposure Risk Assessment in Indian Population. Journal of Food Science, 83(12), 3126-3133. https://doi.org/10.1111/1750-3841.14404.es_CO
dc.relation.referencesRai, A; Das, M y Tripathi, A. (2020). Occurrence and toxicity of a fusarium mycotoxin, zearalenone. Critical Reviews in Food Science and Nutrition, 60(16), 2710-2729. https://doi.org/10.1080/10408398.2019.1655388.es_CO
dc.relation.referencesRai, NK; Tripathi, K; Sharma, D y Shukla, VK. (2005). Apoptosis: A Basic Physiologic Process in Wound Healing. The International Journal of Lower Extremity Wounds, 4(3), 138-144. https://doi.org/10.1177/1534734605280018.es_CO
dc.relation.referencesRajendran, P; Ammar, RB; Al-Saeedi, FJ; Mohamed, ME; ElNaggar, MA; Al-Ramadan, SY; Bekhet, GM y Soliman, AM. (2021). Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In.es_CO
dc.relation.referencesBen, Salem, I; Prola, A; Boussabbeh, M; Guilbert, A; Bacha, H; Abid-Essefi, S y Lemaire, C. (2015). Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenoneinduced apoptosis by reducing endoplasmic reticulum stress. Cell Stress and Chaperones, 20(6). pp.927-938. https://doi.org/10.1007/s12192-015-0613-0.es_CO
dc.relation.referencesVivo Studies. International Journal of Molecular Sciences, 22(1), 217. https://doi.org/10.3390/ijms22010217.es_CO
dc.relation.referencesRamaswamy, M; Deng, M y Siegel, RM. (2011). Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases. Nature Reviews Rheumatology, 7(3), 152-160. https://doi.org/10.1038/nrrheum.2010.225.es_CO
dc.relation.referencesRami, A. (2003). Ischemic neuronal death in the rat hippocampus: The calpain–calpastatin– caspase hypothesis. Neurobiology of Disease, 13(2), 75-88. https://doi.org/10.1016/S0969- 9961(03)00018-4.es_CO
dc.relation.referencesRawlings, ND; Barrett, AJ y Bateman, A. (2010). MEROPS: The peptidase database. Nucleic Acids Research, 38(suppl_1), D227-D233. https://doi.org/10.1093/nar/gkp971.es_CO
dc.relation.referencesReynolds, ES. (1963). The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. The Journal of Cell Biology, 17, 208-212. https://doi.org/10.1083/jcb.17.1.208.es_CO
dc.relation.referencesRichetti, A; Cavallaro, A; Ainis, T y Fimiani, V. (2003). Effect of some mycotoxins on superoxide anion production of isolated human neutrophils and in whole blood. Immunopharmacology and Immunotoxicology, 25(3), 441-449. https://doi.org/10.1081/iph-120024511.es_CO
dc.relation.referencesRiss, TL; Moravec, RA; Niles, AL; Duellman, S; Benink, HA; Worzella, TJ y Minor, L. (2016). Cell Viability Assays. En Assay Guidance Manual [Internet]. Eli Lilly & Company and the National Center for Advancing Translational Sciences. https://www.ncbi.nlm.nih.gov/books/NBK144065/.es_CO
dc.relation.referencesRizzuto, R; Pinton, P; Carrington, W; Fay, FS; Fogarty, KE; Lifshitz, LM; Tuft, RA y Pozzan, T. (1998). Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses. Science, 280(5370), 1763-1766. https://doi.org/10.1126/science.280.5370.1763.es_CO
dc.relation.referencesRodríguez-Carrasco, Y; Moltó, JC; Berrada, H y Mañes, J. (2014). A survey of trichothecenes, zearalenone and patulin in milled grain-based products using GC-MS/MS. Food Chemistry, 146, 212-219. https://doi.org/10.1016/j.foodchem.2013.09.053.es_CO
dc.relation.referencesRogowska, A; Pomastowski, P; Sagandykova, G y Buszewski, B. (2019). Zearalenone and its metabolites: Effect on human health, metabolism and neutralisation methods. Toxicon, 162. pp.46-56. https://doi.org/10.1016/j.toxicon.2019.03.004.es_CO
dc.relation.referencesBennett, JW y Klich, M. (2003). Mycotoxins. Clinical Microbiology Reviews, 16(3), pp. 497-516. https://doi.org/10.1128/CMR.16.3.497-516.2003.es_CO
dc.relation.referencesRojas, Contreras L. (2021). Estudio de la incidencia de aflatoxinas, zearalenona y desoxinivalenol en el arroz producido en las principales zonas arroceras de Colombia [Ph.D. Thesis, Universitat Autònoma de Barcelona]. En TDX (Tesis Doctorals en Xarxa). http://www.tdx.cat/handle/10803/671611.es_CO
dc.relation.referencesRojas, MD; Peterson, DL; Barboza, L; Terán-Ángel, G; Labastida-Moreno, CA; Berrueta, L y Salmen, S. (2014). Programmed hepatocytes cell death associated with FLIP downregulation in response to extracellular preS1/2. Journal of Medical Virology, 86(3), 496-504. https://doi.org/10.1002/jmv.23859.es_CO
dc.relation.referencesRopejko, K y Twarużek, M. (2021). Zearalenone and Its Metabolites—General Overview, Occurrence, and Toxicity. Toxins, 13(1), 35. https://doi.org/10.3390/toxins13010035.es_CO
dc.relation.referencesSaelens, X; Festjens, N; Walle, LV; Gurp, M; Van, Loo G; Van, y Vandenabeele, P. (2004). Toxic proteins released from mitochondria in cell death. Oncogene, 23(16), 2861 -2874. https://doi.org/10.1038/sj.onc.1207523.es_CO
dc.relation.referencesSakamuru, S; Attene-Ramos, MS y Xia, M. (2016). Mitochondrial Membrane Potential Assay. En H. Zhu y M. Xia (Eds.), High-Throughput Screening Assays in Toxicology (Vol. 1473, pp. 17-22). Springer New York. https://doi.org/10.1007/978-1-4939-6346-1_2.es_CO
dc.relation.referencesSakamuru, S; Li, X; Attene-Ramos, MS; Huang, R; Lu, J; Shou, L; Shen, M; Tice, RR; Austin, CP y Xia, M. (2012). Application of a homogenous membrane potential assay to assess mitochondrial function. Physiological Genomics, 44(9), 495-503. https://doi.org/10.1152/physiolgenomics.00161.2011.es_CO
dc.relation.referencesSang, Y; Li, W y Zhang, G. (2016). The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone. Food & Function, 7(9), 3703-3715. https://doi.org/10.1039/C6FO00191B.es_CO
dc.relation.referencesSaraste, A y Pulkki, K. (2000). Morphologic and biochemical hallmarks of apoptosis. Cardiovascular Research, 45(3), 528-537. https://doi.org/10.1016/S0008-6363(99)00384- 3.es_CO
dc.relation.referencesSavi, GD; Piacentini, KC; Rocha, LO; Carnielli-Queiroz, L; Furtado, BG; Scussel, R; Zanoni, ET; Machado-De-Ávila, RA; Corrêa, B y Angioletto, E. (2018). Incidence of toxigenic fungi and zearalenone in rice grains from Brazil. International Journal of Food Microbiology, 270, 5-13. https://doi.org/10.1016/j.ijfoodmicro.2018.02.004.es_CO
dc.relation.referencesSchimmer, AD. (2004). Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice. Cancer Research, 64(20), 7183-7190. https://doi.org/10.1158/0008-5472.CAN- 04-1918.es_CO
dc.relation.referencesBlond-Elguindi, S; Fourie, AM; Sambrook, JF y Gething, MJ. (1993). Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers. Journal of Biological Chemistry, 268(17), 12730-12735. https://doi.org/10.1016/S0021 -9258(18)31449-2.es_CO
dc.relation.referencesSchmit, T; Klomp, M y Khan, MN. (2021). An Overview of Flow Cytometry: Its Principles and Applications in Allergic Disease Research. Methods in Molecular Biology (Clifton, N.J.), 2223, 169-182. https://doi.org/10.1007/978-1-0716-1001-5_13.es_CO
dc.relation.referencesSchuler, M y Green, DR. (2001). Mechanisms of p53-dependent apoptosis. Biochemical Society Transactions, 29(6), 684-688. https://doi.org/10.1042/bst0290684.es_CO
dc.relation.referencesSciau, Ph. (2016). Chapter Two - Transmission Electron Microscopy: Emerging Investigations for Cultural Heritage Materials. En P. W. Hawkes (Ed.), Advances in Imaging and Electron Physics (Vol. 198, pp. 43-67). Elsevier. https://doi.org/10.1016/bs.aiep.2016.09.002.es_CO
dc.relation.referencesSherma, J y Fried, B. (2005). Thin Layer Chromatographic Analysis of Biological Samples. A Review. Journal of Liquid Chromatography & Related Technologies, 28(15), 2297-2314. https://doi.org/10.1080/10826070500187491.es_CO
dc.relation.referencesShi, B, Su, Y; Chang, S; Sun, Y; Meng, X y Shan, A. (2017). Vitamin C protects piglet liver against zearalenone-induced oxidative stress by modulating expression of nuclear receptors PXR and CAR and their target genes. Food & Function, 8(10). pp. 3675-3687. https://doi.org/10.1039/C7FO01301A.es_CO
dc.relation.referencesShier, WT; Shier, AC; Xie, W y Mirocha, CJ. (2001). Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon: Official Journal of the International Society on Toxinology, 39(9), 1435-1438. https://doi.org/10.1016/s0041 - 0101(00)00259-2.es_CO
dc.relation.referencesSingh, N y Bose, K. (2015). Apoptosis: Pathways, Molecules and Beyond. En K. Bose (Ed.), Proteases in Apoptosis: Pathways, Protocols and Translational Advances (pp. 1-30). Springer International Publishing. https://doi.org/10.1007/978-3-319-19497-4_1.es_CO
dc.relation.referencesSingh, BK; Tiwari, S y Dubey, NK. (2021). Essential oils and their nanoformulations as green preservatives to boost food safety against mycotoxin contamination of food commodities: A review. Journal of the Science of Food and Agriculture, 101(12), 4879-4890. https://doi.org/10.1002/jsfa.11255.es_CO
dc.relation.referencesSivandzade, F; Bhalerao, A y Cucullo, L. (2019). Analysis of the Mitochondrial Membrane Potential Using the Cationic JC-1 Dye as a Sensitive Fluorescent Probe. BIO-PROTOCOL, 9(1). https://doi.org/10.21769/BioProtoc.3128.es_CO
dc.relation.referencesSmith, MC; Madec, S; Coton, E y Hymery, N. (2016). Natural Co-Occurrence of Mycotoxins in Foods and Feeds and Their in vitro Combined Toxicological Effects. Toxins, 8(4), 1-36. https://doi.org/10.3390/toxins8040094.es_CO
dc.relation.referencesBoersma, HH; Bennaghmouch, A; Hofstra, L; Narula, J; Heidendal, G K y Reutelingsperger, C. P. M. (s. f.). Past, Present, and Future of Annexin A5: From Protein Discovery to Clinical Applications. 16.es_CO
dc.relation.referencesSmyth, PG y Berman, SA. (2002). Markers of apoptosis: Methods for elucidating the mechanism of apoptotic cell death from the nervous system. BioTechniques, 32(3), 648-650, 652, 654 passim. https://doi.org/10.2144/02323dd02.es_CO
dc.relation.referencesSo, MY; Tian, Z; Phoon, YS; Sha, S;Antoniou, MN; Zhang, J; Wu, RSS y Tan-Un, KC. (2014). Gene Expression Profile and Toxic Effects in Human Bronchial Epithelial Cells Exposed to Zearalenone. PLOS ONE, 9(5), e96404. https://doi.org/10.1371/journal.pone.0096404.es_CO
dc.relation.referencesSouza, WCO; Nascimento, LC; Oliveira, MDM; Porcino, MM y Silva, HAO. (2018). Genetic diversity of Fusarium spp. In pineapple ‘Pérola’ cultivar. European Journal of Plant Pathology, 150(4), 853-868. https://doi.org/10.1007/s10658-017-1328-0.es_CO
dc.relation.referencesSpringler, A: Hessenberger, S; Reisinger, N; Kern, C; Nagl, V; Schatzmayr, G y Mayer, E. (2017). Deoxynivalenol and its metabolite deepoxy-deoxynivalenol: Multi-parameter analysis for the evaluation of cytotoxicity and cellular effects. Mycotoxin Research, 33(1), 25-37. https://doi.org/10.1007/s12550-016-0260-z.es_CO
dc.relation.referencesStakheev, A. A., Erokhin, D. V., Meleshchuk, E. A., Mikityuk, O. D., y Statsyuk, N. V. (2022). Effect of Compactin on the Mycotoxin Production and Expression of Related Biosynthetic and Regulatory Genes in Toxigenic Fusarium culmorum. Microorganisms, 10(7), 1347. https://doi.org/10.3390/microorganisms10071347.es_CO
dc.relation.referencesStępień, Ł; Koczyk, G y Waśkiewicz, A. (2013). Diversity of Fusarium species and mycotoxins contaminating pineapple. Journal of Applied Genetics, 54(3), 367-380. https://doi.org/10.1007/s13353-013-0146-0.es_CO
dc.relation.referencesStrasser, A. (2005). The role of BH3-only proteins in the immune system. Nature Reviews Immunology, 5(3), 189-200. https://doi.org/10.1038/nri1568.es_CO
dc.relation.referencesSummerell, BA; Salleh, B y Leslie, JF. (2003). A Utilitarian Approach to Fusarium Identification. Plant Disease, 87(2), 117-128. https://doi.org/10.1094/PDIS.2003.87.2.117.es_CO
dc.relation.referencesSun, L; Dai, J; Xu, J; Yang, J y Zhang, D. (2022). Comparative Cytotoxic Effects and Possible Mechanisms of Deoxynivalenol, Zearalenone and T-2 Toxin Exposure to Porcine Leydig Cells In Vitro. Toxins, 14(2), 113. https://doi.org/10.3390/toxins14020113.es_CO
dc.relation.referencesTamura, M; Mochizuki, N; Nagatomi, Y; Harayama, K; Toriba, A y Hayakawa, K. (2015). A method for simultaneous determination of 20 Fusarium toxins in cereals by high-resolution liquid chromatography-Orbitrap mass spectrometry with a pentafluorophenyl column. Toxins, 7(5), 1664-1682. https://doi.org/10.3390/toxins7051664.es_CO
dc.relation.referencesBoersma, HH; Kietselaer, BL; Stolk, LM; Bennaghmouch, A; Hofstra, L; Narula, J y Reutelingsperger, CP. (2005). Past, present, and future of annexin A5: from protein discovery to clinical applications. Journal of nuclear medicine, 46(12), 2035-2050.es_CO
dc.relation.referencesTatay, E; Espín, S; García-Fernández, AJ y Ruiz, MJ. (2017). Oxidative damage and disturbance of antioxidant capacity by zearalenone and its metabolites in human cells. Toxicology in Vitro, 45, 334-339. https://doi.org/10.1016/j.tiv.2017.04.026.es_CO
dc.relation.referencesTatay, E; Font, G y Ruiz, MJ. (2016). Cytotoxic effects of zearalenone and its metabolites and antioxidant cell defense in CHO-K1 cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 96, 43-49. https://doi.org/10.1016/j.fct.2016.07.027.es_CO
dc.relation.referencesTatay, E; Meca, G; Font, G y Ruiz, MJ. (2014). Cytotoxic and interactive effects of zearalenone, alpha-zearalenol and beta-zearalenol and formation of metabolites in HepG2 cells. Rev. Toxicol, 187-195.es_CO
dc.relation.referencesTobey, RA. (1975). Different drugs arrest cells at a number of distinct stages in G2. Nature, 254(5497), 245-247. https://doi.org/10.1038/254245a0.es_CO
dc.relation.referencesBritannica. (s. f.). Transmission electron microscope | instrument | Britannica. Recuperado 10 de julio de 2022, de https://www.britannica.com/technology/transmission-electronmicroscope.es_CO
dc.relation.referencesTravers, KJ; Patil, CK; Wodicka, L; Lockhart, DJ; Weissman, JS y Walter, P. (2000). Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell, 101(3), 249-258. https://doi.org/10.1016/s0092-8674(00)80835-1.es_CO
dc.relation.referencesTuchin, VV; Tárnok, A y Zharov, VP. (2011). In vivo flow cytometry: A horizon of opportunities. Cytometry Part A, 79A(10), 737-745. https://doi.org/10.1002/cyto.a.21143.es_CO
dc.relation.referencesUrry, WH; Wehrmeister, HL; Hodge, EB y Hidy, PH. (1966). The structure of zearalenone. Tetrahedron Letters, 7(27), 3109-3114. https://doi.org/10.1016/S0040-4039(01)99923-X.es_CO
dc.relation.referencesVan, Loo G; Van, Gurp M; Depuydt, B; Srinivasula, SM; Rodriguez, I; Alnemri, ES; Gevaert, K; Vandekerckhove, J; Declercq, W y Vandenabeele, P. (2002). The serine protease Omi/HtrA2 is released from, mitochondria during apoptosis. Omi interacts with caspaseinhibitor XIAP and induces enhanced caspase activity. Cell Death and Differentiation, 9(1), 20-26. https://doi.org/10.1038/sj.cdd.4400970.es_CO
dc.relation.referencesVerhulst, C; Coiffard, C; Coiffard, LJM; Rivalland, P y De Roeck-Holtzhauer, Y. (1998). In vitro correlation between two colorimetric assays and the pyruvic acid consumption by fibroblasts cultured to determine the sodium laurylsulfate cytotoxicity. Journal of Pharmacological and Toxicological Methods, 39(3), 143-146. https://doi.org/10.1016/S1056-8719(98)00016-1.es_CO
dc.relation.referencesBooth, C. (1977). Fusarium: Laboratory guide to the identification of the major species. Commonwealth Mycological Institute.es_CO
dc.relation.referencesViera, Limon MJ; Morlett, Chavez JA; Sierra, Rivera CA; Contreras, DL y Zugasti-Cruz, A. (2015). Zearalenone Induced Cytotoxicity and Oxidative Stress in Human Peripheral Blood Leukocytesevita. Toxicology: Open Access, 01(01). https://doi.org/10.4172/2476- 2067.1000102.es_CO
dc.relation.referencesVirk, P; Al-mukhaizeem, NAR; Bin, Morebah SH; Fouad, D y Elobeid, M. (2020). Protective effect of resveratrol against toxicity induced by the mycotoxin, zearalenone in a rat model. Food and Chemical Toxicology, 146, 111840. https://doi.org/10.1016/j.fct.2020.111840.es_CO
dc.relation.referencesVlata, Z; Porichis, F; Tzanakakis, G; Tsatsakis, A y Krambovitis, E. (2006). A study of zearalenone cytotoxicity on human peripheral blood mononuclear cells. Toxicology Letters, 165(3). pp. 274-281. https://doi.org/10.1016/j.toxlet.2006.05.001.es_CO
dc.relation.referencesVousden, KH y Lane, DP. (2007). P53 in health and disease. Nature Reviews Molecular Cell Biology, 8(4), 275-283. https://doi.org/10.1038/nrm2147.es_CO
dc.relation.referencesWajant, H. (2002). The Fas Signaling Pathway: More Than a Paradigm. Science, 296(5573), 1635- 1636. https://doi.org/10.1126/science.1071553.es_CO
dc.relation.referencesWanga, DB; Kinoshita, C; Kinoshita, Y y Morrison, RS. (2014). P53 and mitochondrial function in neurons. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842(8), 1186-1197. https://doi.org/10.1016/j.bbadis.2013.12.015.es_CO
dc.relation.referencesWangb, S y El-Deiry, WS. (2004). Cytochrome c: A crosslink between the mitochondria and the endoplasmic reticulum in calcium-dependent apoptosis. Cancer Biology & Therapy, 3(1), 44-46. https://doi.org/10.4161/cbt.3.1.740.es_CO
dc.relation.referencesWangc, Y; Zheng, W; Bian, X; Yuan, Y; Gu, J; Liu, X; Liu, Z y Bian, J. (2014). Zearalenone induces apoptosis and cytoprotective autophagy in primary Leydig cells. Toxicology Letters, 226(2), 182-191. https://doi.org/10.1016/j.toxlet.2014.02.003.es_CO
dc.relation.referencesWang, X; Yu, H; Fang, H; Zhao, Y; Jin, Y; Shen, J; Zhou, C; Zhou, Y; Fu, Y; Wang, J y Zhang, J. (2019). Transcriptional profiling of zearalenone-induced inhibition of IPEC-J2 cell proliferation. Toxicon: Official Journal of the International Society on Toxinology, 172, 8-14. https://doi.org/10.1016/j.toxicon.2019.10.004.es_CO
dc.relation.referencesWatson, ML. (1958). Staining of Tissue Sections for Electron Microscopy with Heavy Metals. The Journal of Biophysical and Biochemical Cytology, 4(4), 475-478. https://doi.org/10.1083/jcb.4.4.475.es_CO
dc.relation.referencesBossy-Wetzel, E y Green, DR. (2000). Assays for cytochrome c release from mitochondria during apoptosis. Methods in Enzymology, 322, 235-242. https://doi.org/10.1016/s0076- 6879(00)22024-7.es_CO
dc.relation.referencesWentzel, JF, Lombard, MJ; Du Plessis, LH y Zandberg, L. (2017). Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins. Archives of Toxicology, 91(5), 2265-2282. https://doi.org/10.1007/s00204-016-1872-y.es_CO
dc.relation.referencesWilkerson, MJ. (2012). Principles and Applications of Flow Cytometry and Cell Sorting in Companion Animal Medicine. Veterinary Clinics: Small Animal Practice, 42(1), 53-71. https://doi.org/10.1016/j.cvsm.2011.09.012.es_CO
dc.relation.referencesWiney, M; Meehl, JB; O’Toole, ET y Giddings, TH. (2014). Conventional transmission electron microscopy. Molecular Biology of the Cell, 25(3), 319-323. https://doi.org/10.1091/mbc.E12-12-0863.es_CO
dc.relation.referencesXu, C; Bailly-Maitre, B y Reed, JC. (2005). Endoplasmic reticulum stress: Cell life and death decisions. The Journal of Clinical Investigation, 115(10), 2656-2664. https://doi.org/10.1172/JCI26373.es_CO
dc.relation.referencesXu, ML; Hu, J; Guo, BP; Niu, YR; Xiao, C y Xu, YX. (2016). Exploration of intrinsic and extrinsic apoptotic pathways in zearalenone-treated rat sertoli cells. Environmental Toxicology, 31(12), 1731 -1739. https://doi.org/10.1002/tox.22175.es_CO
dc.relation.referencesYamashima, T. (2004). Ca2+-dependent proteases in ischemic neuronal death: A conserved ‘calpain–cathepsin cascade’ from nematodes to primates. Cell Calcium, 36(3), 285-293. https://doi.org/10.1016/j.ceca.2004.03.001.es_CO
dc.relation.referencesYang, JY; Wang, GX; Liu, JL; Fan, JJ y Cui, S. (2007). Toxic effects of zearalenone and its derivatives α-zearalenol on male reproductive system in mice. Reproductive Toxicology, 24(3), 381-387. https://doi.org/10.1016/j.reprotox.2007.05.009.es_CO
dc.relation.referencesYang, LJ; Zhou, M; Huang, LB; Yang, WR; Yang, ZB; Jiang, SZ y Ge, JS. (2018). ZearalenonePromoted Follicle Growth through Modulation of Wnt-1/β-Catenin Signaling Pathway and Expression of Estrogen Receptor Genes in Ovaries of Postweaning Piglets. Journal of Agricultural and Food Chemistry, 66(30), 7899-7906. https://doi.org/10.1021/acs.jafc.8b02101.es_CO
dc.relation.referencesYazar, S y Omurtag, GZ. (2008). Fumonisins, Trichothecenes and Zearalenone in Cereals. International Journal of Molecular Sciences, 9(11), pp. 2062-2090. https://doi.org/10.3390/ijms9112062.es_CO
dc.relation.referencesYin, S; Liu, X; Fan, L y Hu, H. (2018). Mechanisms of cell death induction by food-borne mycotoxins. Critical Reviews in Food Science and Nutrition, 58(8), 1406-1417. https://doi.org/10.1080/10408398.2016.1260526.es_CO
dc.relation.referencesBottalico, A. (1998). Fusarium diseases of cereals: species complex and related mycotoxin profiles, in Europe. Journal of Plant Pathology, 80(2). pp. 85-103.es_CO
dc.relation.referencesYu, JY; Zheng, ZH; Son, YO; Shi, X; Jang, YO y Lee, JC. (2011). Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages. Toxicology in Vitro, 25(8), 1654-1663. https://doi.org/10.1016/j.tiv.2011.07.002.es_CO
dc.relation.referencesYu, M; Chen, L; Peng, Z; Wang, D; Song, Y; Wang, H; Yao, P; Yan, H; Nüssler, AK; Liu, L; y Yang, W. (2017). Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway. Toxins, 9(6), 188. https://doi.org/10.3390/toxins9060188.es_CO
dc.relation.referencesYu, Z; Zhang, L; Wu, D y Liu, F. (2005). Anti-apoptotic action of zearalenone in MCF-7 cells. Ecotoxicology and Environmental Safety, 62(3), 441 -446. https://doi.org/10.1016/j.ecoenv.2004.10.003.es_CO
dc.relation.referencesYue, J y López, JM. (2020). Understanding MAPK Signaling Pathways in Apoptosis. International Journal of Molecular Sciences, 21(7), 2346. https://doi.org/10.3390/ijms21072346.es_CO
dc.relation.referencesZaied, C; Zouaoui, N; Bacha, H y Abid, S. (2012). Natural occurrence of zearalenone in Tunisian wheat grains. Food Control, 25(2), 773-777. https://doi.org/10.1016/j.foodcont.2011.12.012.es_CO
dc.relation.referencesZain, ME. (2011). Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society, 15(2), 129-144. https://doi.org/10.1016/j.jscs.2010.06.006.es_CO
dc.relation.referencesZamzami, N; Métivier, D y Kroemer, G. (2000). Quantitation of Mitochondrial Transmembrane Potential in Cells and in Isolated Mitochondria. Methods in Enzymology, 322, 208-213. https://doi.org/10.1016/S0076-6879(00)22021-1.es_CO
dc.relation.referencesZhanga, GL; Feng, YL; Song, JL y Zhou, XS. (2018). Zearalenone: A Mycotoxin With Different Toxic Effect in Domestic and Laboratory Animals’ Granulosa Cells. Frontiers in Genetics, 9, 667. https://doi.org/10.3389/fgene.2018.00667.es_CO
dc.relation.referencesZhang, GL; Sun, XF; Feng, YZ; Li, B; Li, YP; Yang, F; Nyachoti, CM; Shen, W; Sun, SD y Li, L. (2017). Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro. Toxicology and Applied Pharmacology, 317, 33-40. https://doi.org/10.1016/j.taap.2017.01.004.es_CO
dc.relation.referencesZhangb, K; Tan, X; Li, Y; Liang, G; Ning, Z; Ma, Y y Li, Y. (2018). Transcriptional profiling analysis of Zearalenone-induced inhibition proliferation on mouse thymic epithelial cell line 1. Ecotoxicology and Environmental Safety, 153, 135-141. https://doi.org/10.1016/j.ecoenv.2018.01.005.es_CO
dc.relation.referencesBouaziz, C; Sharaf el Dein, O; Martel, C; Golli, EE, Abid-Essefi, S; Brenner, C; Lemaire, C y Bacha, H. (2011). Molecular events involved in ochratoxin A induced mitochondrial pathway of apoptosis, modulation by Bcl-2 family members. Environmental Toxicology, 26(6), 579-590. https://doi.org/10.1002/tox.20581.es_CO
dc.relation.referencesZheng, W; Pan, S; Wang, G; Wang, YJ; Liu, Q; Gu, J; Yuan, Y; Liu, XZ; Liu, ZP y Bian, JC. (2016). Zearalenone impairs the male reproductive system functions via inducing structural and functional alterations of sertoli cells. Environmental Toxicology and Pharmacology, 42, 146-155. https://doi.org/10.1016/j.etap.2016.01.013.es_CO
dc.relation.referencesZhenga, W; Wang, B; Li, X; Wang, T; Zou, H; Gu, J; Yuan, Y; Liu, X; Bai, J; Bian, J y Liu, Z. (2018). Zearalenone Promotes Cell Proliferation or Causes Cell Death? Toxins, 10(5), 184. https://doi.org/10.3390/toxins10050184.es_CO
dc.relation.referencesZhengb, WL; Wang, BJ; Wang, L; Shan, YP; Zou, H; Song, RL; Wang, T; Gu, JH; Yuan, Y; Liu, XZ; Zhu, GQ; Bai, JF; Liu, ZP y Bian, JC. (2018). ROS-Mediated Cell Cycle Arrest and Apoptosis Induced by Zearalenone in Mouse Sertoli Cells via ER Stress and the ATP/AMPK Pathway. Toxins, 10(1), 24. https://doi.org/10.3390/toxins10010024.es_CO
dc.relation.referencesZhou, C; Zhang, Y; Yin, S; Jia, Z y Shan, A. (2015). Biochemical changes and oxidative stress induced by zearalenone in the liver of pregnant rats. Human & Experimental Toxicology, 34(1). pp.65-73. https://doi.org/10.1177/0960327113504972.es_CO
dc.relation.referencesZiegler, U y Groscurth, P. (2004). Morphological Features of Cell Death. Physiology, 19(3), 124- 128. https://doi.org/10.1152/nips.01519.2004.es_CO
dc.relation.referencesZinedine, A; Soriano, JM; Moltó, JC y Mañes, J. (2007). Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Food and Chemical Toxicology, 45(1), 1-18. https://doi.org/10.1016/j.fct.2006.07.030.es_CO
dc.relation.referencesZong, WX y Thompson, CB. (2006). Necrotic death as a cell fate. Genes & Development, 20(1), 1-15. https://doi.org/10.1101/gad.1376506.es_CO
dc.relation.referencesZuo, JM y Spence, JCH. (2017). Introduction and Historical Background. En J. M. Zuo y J. C. H. Spence (Eds.), Advanced Transmission Electron Microscopy: Imaging and Diffraction in Nanoscience (pp. 1 -18). Springer. https://doi.org/10.1007/978-1-4939-6607-3_1.es_CO
dc.relation.referencesBranzei, D y Foiani, M. (2008). Regulation of DNA repair throughout the cell cycle. Nature Reviews. Molecular Cell Biology, 9(4). pp. 297-308. https://doi.org/10.1038/nrm2351.es_CO
dc.relation.referencesBreckenridge, DG; Germain, M; Mathai, JP; Nguyen, M y Shore, GC. (2003). Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene, 22(53), 8608-8618. https://doi.org/10.1038/sj.onc.1207108.es_CO
dc.relation.referencesBroom, L. (2015). Mycotoxins and the intestine. Animal Nutrition, 1(4), 262-265. https://doi.org/10.1016/j.aninu.2015.11.001.es_CO
dc.relation.referencesBryden, WL. (2012). Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Animal Feed Science and Technology, 173(1), 134-158. https://doi.org/10.1016/j.anifeedsci.2011.12.014.es_CO
dc.relation.referencesCai, G; Si, M; Li, X; Zou, H; Gu, J; Yuan, Y; Liu, X; Liu, Z y Bian, J. (2019). Zearalenone induces apoptosis of rat Sertoli cells through Fas-Fas ligand and mitochondrial pathway. Environmental Toxicology, 34(4), 424-433. https://doi.org/10.1002/tox.22696.es_CO
dc.relation.referencesCai, G; Sun, K; Xia, S; Feng, Z; Zou, H; Gu, J, Yuan, Y; Zhu, J., Liu, Z., y Bian, J. (2020). Decrease in immune function and the role of mitogen-activated protein kinase (MAPK) overactivation in apoptosis during T lymphocytes activation induced by zearalenone, deoxynivalenol, and their combinations. Chemosphere, 255, 126999. https://doi.org/10.1016/j.chemosphere.2020.126999.es_CO
dc.relation.referencesCao, SS, y Kaufman, RJ. (2014). Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & Redox Signaling, 21(3), 396-413. https://doi.org/10.1089/ars.2014.5851.es_CO
dc.relation.referencesCarlson, MP y Ensley, SM. (2003). Sampling and Analyzing Feed for Fungal (Mold) Toxins (Mycotoxins). 4.es_CO
dc.relation.referencesCarlson, MP y Ensley, SM. (2003). Sampling and analyzing feed for fungal (mold) toxins (mycotoxins). Lincoln, NE, USA: Cooperative Extension, Institute of Agriculture and Natural Resources, University of Nebraska-Lincoln.es_CO
dc.relation.referencesChandravarnan, P; Agyei, D y Ali, A. (2022). Green and sustainable technologies for the decontamination of fungi and mycotoxins in rice: A review. Trends in Food Science & Technology, 124, 278-295. https://doi.org/10.1016/j.tifs.2022.04.020.es_CO
dc.relation.referencesChannaiah, L y Maier, D. (2014). Best Stored Maize Management Practices for the Prevention of Mycotoxin Contamination. Capíptulo 6. p. 78-88. https://doi.org/10.1002/9781118832790.es_CO
dc.relation.referencesCharoenpornsook, K; Fitzpatrick, JL y Smith, JE. (1998). The effects of four mycotoxins on the mitogen stimulated proliferation of bovine peripheral blood mononuclear cells in vitro. Mycopathologia, 143(2), 105-111. https://doi.org/10.1023/A:1006971724678.es_CO
dc.relation.referencesChen, F; Li, Q; Zhang, Z; Lin, P; Lei, L; Wang, A Jin, Y. (2015). Endoplasmic Reticulum Stress Cooperates in Zearalenone-Induced Cell Death of RAW 264.7 Macrophages. International Journal of Molecular Sciences, 16(8), 19780-19795. https://doi.org/10.3390/ijms160819780.es_CO
dc.relation.referencesChen, Q; Thompson, J; Hu, Y; Das, A y Lesnefsky, EJ. (2019). Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage. Frontiers in Cardiovascular Medicine, 6. https://www.frontiersin.org/articles/10.3389/fcvm.2019.00010.es_CO
dc.relation.referencesChen, Q; Takeyama, N; Brady, G; Watson, AJ y Dive, C. (1998). Blood cells with reduced mitochondrial membrane potential and cytosolic cytochrome C can survive and maintain clonogenicity given appropriate signals to suppress apoptosis. Blood, 92(12), 4545-4553.es_CO
dc.relation.referencesChinnaiyan, AM. (1999). The apoptosome: Heart and soul of the cell death machine. Neoplasia (New York, N.Y.), 1(1), 5-15. https://doi.org/10.1038/sj.neo.7900003.es_CO
dc.relation.referencesConsejo Ejecutivo, 110. (2002). Informe sobre las reuniones de los comités de expertos y los grupos de estudio: Informe de la Secretaría (EB110/6). Organización Mundial de la Salud. https://apps.who.int/iris/handle/10665/81563.es_CO
dc.relation.referencesCook, SA y Poole-Wilson, PA. (1999). Cardiac myocyte apoptosis. European Heart Journal, 20(22), 1619-1629. https://doi.org/1 0.1053/euhj.1999.1548.es_CO
dc.relation.referencesCrowley, LC; Marfell, BJ; Scott, AP y Waterhouse, NJ. (2016). Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry. Cold Spring Harbor Protocols, 2016(11), pdb.prot087288. https://doi.org/10.1101/pdb.prot087288.es_CO
dc.relation.referencesC.S Reddy, Reddy, KRN; N.R.Kumar, y Muralidharan, K. (2004). Exploration aflatoxin contamination and its management in rice grains. Journal of Mycology and Plant Pathology, 34, 816-820.es_CO
dc.relation.referencesCúcuta nuestra. (s.f.).Los Patios Norte de Santander. https://www.cucutanuestra.com/tema/geografia/municipios/region-centro/los-patios/los patios.htm.es_CO
dc.relation.referencesD’Arcy, MS. (2019). Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biology International, 43(6), 582-592. https://doi.org/10.1002/cbin.11137.es_CO
dc.relation.referencesDaou, R; Joubrane, K; Maroun, RG; Khabbaz, LR; Ismail, A; Khoury, AE; Daou, R; Joubrane, K; Maroun, R G; Khabbaz, L. R., Ismail, A., y Khoury, A. E. (2021). Mycotoxins: Factors influencing production and control strategies. AIMS Agriculture and Food, 6(1), 416-447. https://doi.org/10.3934/agrfood.2021025.es_CO
dc.relation.referencesDANE (2017). Características que se destacan en el cultivo de arroz secano (Oryza Sativa L.) en Colombia. Boletín mensual insumos y factores asociados a la producción agropecuaria n°58. disponible en: https://www.dane.gov.co/files/investigaciones/agropecuario/sipsa/bol_insumos_abr_2017 .pdf, fecha de consulta 8-05-2020.es_CO
dc.relation.referencesDarbre, P; Byford, R; Shaw, L; Horton, R; Pope, G y Sauer, M. (2002). Oestogenic activity of isobutylparaben in vitro and in vivo. Journal of applied toxicology : JAT, 22, 219-226. https://doi.org/10.1002/jat.860.es_CO
dc.relation.referencesDarzynkiewicz, Z; Galkowski, D y Zhao, H. (2008). Analysis of apoptosis by cytometry using TUNEL assay. Methods (San Diego, Calif.), 44(3), 250-254. https://doi.org/10.1016/j.ymeth.2007.11.008.es_CO
dc.relation.referencesDemchenko, AP. (2013). Beyond annexin V: Fluorescence response of cellular membranes to apoptosis. Cytotechnology, 65(2), 157-172. https://doi.org/10.1007/s10616-012-9481-y.es_CO
dc.relation.referencesDíaz, M; Herrero, M; García, LA y Quirós, C. (2010). Application of flow cytometry to industrial microbial bioprocesses. Biochemical Engineering Journal, 48(3), 385-407. https://doi.org/10.1016/j.bej.2009.07.013.es_CO
dc.relation.referencesD’Mello, JPF; Placinta, CM. y Macdonald, AMC. (1999). Fusarium mycotoxins: A review of global implications for animal health, welfare and productivity. Animal Feed Science and Technology, 80(3). pp.183-205. https://doi.org/10.1016/S0377-8401(99)00059-0.es_CO
dc.relation.referencesDors, G. C., Bierhals, V. da S., y Badiale-Furlong, E. (2011). Parboiled rice: Chemical composition and the occurrence of mycotoxins. Food Science and Technology, 31, 172-177.es_CO
dc.relation.referencesDu, C; Fang, M; Li, Y; Li, L y Wang, X. (2000). Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102(1), 33-42. https://doi.org/10.1016/s0092-8674(00)00008-8.es_CO
dc.relation.referencesDuarte-Vogel, S y Villamil-Jiménez, LC. (2006). Micotoxinas en la Salud Pública. Revista de Salud Pública, 8(1), pp. 129-135. https://doi.org/10.1590/S0124-00642006000400011.es_CO
dc.relation.referencesEdinger, AL y Thompson, CB. (2004). Death by design: Apoptosis, necrosis and autophagy. Current Opinion in Cell Biology, 16(6), 663-669. https://doi.org/10.1016/j.ceb.2004.09.011.es_CO
dc.relation.referencesDa Rocha, M. E. B., Freire, F. D. C. O., Maia, F. E. F., Guedes, M. I. F., & Rondina, D. (2014). Mycotoxins and their effects on human and animal health. Food Control, 36(1), 159-165.es_CO
dc.relation.referencesEguchi, Y; Shimizu, S y Tsujimoto, Y. (1997). Intracellular ATP Levels Determine Cell Death Fate by Apoptosis or Necrosis1. Cancer Research, 57(10), 1835-1840.es_CO
dc.relation.referencesEl Golli Bennour, E; Bouaziz, C; Ladjimi, M; Renaud, F y Bacha, H. (2009). Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: Is oxidative stress a common process? Environmental Toxicology, 24(6), 538-548. https://doi.org/10.1002/tox.20449.es_CO
dc.relation.referencesElmore, S. (2007). Apoptosis: A Review of Programmed Cell Death. Toxicologic Pathology, 35(4), 495-516. https://doi.org/10.1080/01926230701320337.es_CO
dc.relation.referencesEscobar, ML; Echeverría, OM y Vázquez-Nin, GH. (2015). Necrosis as Programmed Cell Death. En Cell Death—Autophagy, Apoptosis and Necrosis. IntechOpen. https://doi.org/10.5772/61483.es_CO
dc.relation.referencesFAO - 28a Conferencia Regional De La FAO Para América Latina y El Caribe. (s. f.). Recuperado 10 de julio de 2022, de https://www.fao.org/3/J1225s/J1225s00.htm.es_CO
dc.relation.referencesFedearroz (1998). Censo Nacional Arrocero. Cubrimiento cosecha. Fondo nacional del arroz División de investigaciones económicas 2(B). pp.167-197.es_CO
dc.relation.referencesFedearroz. (2012). El clima y el cultivo del arroz en Norte de Santander. Revista de arroz. Cúcuta. En: FEDEARROZ. 2012, Vol. 60, No. 497.es_CO
dc.relation.referencesFeng, N; Wang, B; Cai, P; Zheng, W; Zou, H; Gu, J; Yuan, Y; Liu, X; Liu, Z y Bian, J. (2020). ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum. Toxicology Letters, 323, 1-9. https://doi.org/10.1016/j.toxlet.2020.01.010.es_CO
dc.relation.referencesFleisher, TA y Oliveira, JB. (2019). 92—Flow Cytometry. En R. R. Rich, T. A. Fleisher, W. T. Shearer, H. W. Schroeder, A. J. Frew, y C. M. Weyand (Eds.), Clinical Immunology (Fifth Edition) (pp. 1239-1251.e1). Elsevier. https://doi.org/10.1016/B978-0-7020-6896- 6.00092-2.es_CO
dc.relation.referencesFormigli, L; Papucci, L; Tani, A; Schiavone, N; Tempestini, A; Orlandini, GE; Capaccioli, S y Zecchi Orlandini, S. (2000). Aponecrosis: Morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. Journal of Cellular Physiology, 182(1), 41-49. https://doi.org/10.1002/(SICI)1097- 4652(200001)182:1<41::AID-JCP5>3.0.CO;2-7.es_CO
dc.relation.referencesGaffoor, I., y Trail, F. (2006). Characterization of Two Polyketide Synthase Genes Involved in Zearalenone Biosynthesis in Gibberella zeae. Applied and Environmental Microbiology, 72(3), 1793-1799. https://doi.org/10.1128/AEM.72.3.1793-1799.2006.es_CO
dc.relation.referencesGaffoor, I., y Trail, F. (2006). Characterization of Two Polyketide Synthase Genes Involved in Zearalenone Biosynthesis in Gibberella zeae. Applied and Environmental Microbiology, 72(3), 1793-1799. https://doi.org/10.1128/AEM.72.3.1793-1799.2006.es_CO
dc.relation.referencesGarzón-González, HD; Jaimes-Méndez, N; Rojas-Contreras, L; Salmen-Halabi, S y Gil-Durán, MA. (2021). Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2. Revista MVZ Córdoba, 26(3), e2080-e2080. https://doi.org/10.21897/rmvz.2080.es_CO
dc.relation.referencesGasser, JP; Hehl, M y Millward, TA. (2009). A homogeneous time-resolved fluorescence resonance energy transfer assay for phosphatidylserine exposure on apoptotic cells. Analytical Biochemistry, 384(1), 49-55. https://doi.org/10.1016/j.ab.2008.09.016.es_CO
dc.relation.referencesGavrieli, Y; Sherman, Y y Ben-Sasson, SA. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. The Journal of Cell Biology, 119(3), 493-501. https://doi.org/10.1083/jcb.119.3.493.es_CO
dc.relation.referencesGazzah, AC; Camoin, L; Abid, S; Bouaziz, C; Ladjimi, M y Bacha, H. (2013). Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone. Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 65(6), 809-816. https://doi.org/10.1016/j.etp.2012.11.007.es_CO
dc.relation.referencesGazzah, AC; El Golli Bennour, E; Bouaziz, C; Abid, S; Ladjimi, M y Bacha, H. (2010). Sequential events of apoptosis induced by zearalenone in cultured hepatocarcinoma cells. Mycotoxin Research, 26(3), 187-197. https://doi.org/10.1007/s12550-010-0053-8.es_CO
dc.relation.referencesGimeno, A y Martins, ML. (2011). Micotoxinas y micotoxicosis en animales y humanos. Special Nutrients, Florida, 50-53.es_CO
dc.relation.referencesGolge, O y Kabak, B. (2020). Occurrence of deoxynivalenol and zearalenone in cereals and cereal products from Turkey. Food Control, 110, 106982. https://doi.org/10.1016/j.foodcont.2019.106982.es_CO
dc.relation.referencesGraham, L y Orenstein, JM. (2007). Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nature Protocols, 2(10), 2439-2450. https://doi.org/10.1038/nprot.2007.304.es_CO
dc.relation.referencesGreen, DR y Reed, JC. (1998). Mitochondria and Apoptosis. Science, 281(5381), 1309-1312. https://doi.org/10.1126/science.281.5381.1309.es_CO
dc.relation.referencesGrimsley, C y Ravichandran, KS. (2003). Cues for apoptotic cell engulfment: Eat-me, don’t eatme and come-get-me signals. Trends in Cell Biology, 13(12), 648-656. https://doi.org/10.1016/j.tcb.2003.1 0.004.es_CO
dc.relation.referencesGromadzka, K; Waskiewicz, A; Chelkowski, J y Golinski, P. (2008). Zearalenone and its metabolites: Occurrence, detection, toxicity and guidelines. World Mycotoxin Journal, 1(2). pp.209-220. https://doi.org/10.3920/WMJ2008.x015.es_CO
dc.relation.referencesGross, A; Yin, XM; Wang, K; Wei, MC; Jockel, J; Milliman, C; Erdjument-Bromage, H; Tempst, P y Korsmeyer, SJ. (1999). Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death *. Journal of Biological Chemistry, 274(2), 1156-1163. https://doi.org/10.1074/jbc.274.2.1156.es_CO
dc.relation.referencesGupta, RC; Mostrom, MS y Evans, TJ. (2018). Chapter 76—Zearalenone. En R. C. Gupta (Ed.), Veterinary Toxicology (Third Edition). pp. 1055-1063. Academic Press. https://doi.org/10.1016/B978-0-12-811410-0.00076-3.es_CO
dc.relation.referencesHadiani, MR; Yazdanpanah, H; Ghazi-Khansari, MM. Cheraghali, A y Goodarzi, M. (2003). Survey of the natural occurrence of zearalenone in maize from northern Iran by thin-layer chromatography densitometry. Food Additives & Contaminants, 20(4), 380-385. https://doi.org/10.1080/0265203031000087968.es_CO
dc.relation.referencesHan, Y y Lo, YH. (2015). Imaging Cells in Flow Cytometer Using Spatial-Temporal Transformation. Scientific Reports, 5(1), 13267. https://doi.org/10.1038/srep13267.es_CO
dc.relation.referencesHansen, FT; Sørensen, JL; Giese, H; Sondergaard, TE y Frandsen, RJN. (2012). Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium. International Journal of Food Microbiology, 155(3), 128-136. https://doi.org/10.1016/j.ijfoodmicro.2012.01.018.es_CO
dc.relation.referencesHartley, A; Stone, JM; Heron, C; Cooper, JM y Schapira, AHV. (1994). Complex I Inhibitors Induce Dose-Dependent Apoptosis in PC12 Cells: Relevance to Parkinson’s Disease. Journal of Neurochemistry, 63(5), 1987-1990. https://doi.org/10.1046/j.1471 - 4159.1994.63051987.x.es_CO
dc.relation.referencesHassan, M; Watari, H; AbuAlmaaty, A; Ohba, Y y Sakuragi, N. (2014). Apoptosis and molecular targeting therapy in cancer. BioMed Research International. https://go.gale.com/ps/i.do?p=AONE&sw=w&issn=23146133&v=2.1&it=r&id=GALE% 7CA427021940&sid=googleScholar&linkaccess=abs.es_CO
dc.relation.referencesHassen, W; El Golli, E; Baudrimont, I; Mobio, AT; Ladjimi, MM; Creppy, EE y Bacha, H. (2005). Cytotoxicity and Hsp 70 induction in Hep G2 cells in response to zearalenone and cytoprotection by sub-lethal heat shock. Toxicology, 207(2), 293-301. https://doi.org/10.1016/j.tox.2004.10.001.es_CO
dc.relation.referencesHeatwole, VM. (1999). TUNEL Assay for Apoptotic Cells. En L. C. Javois, Immunocytochemical Methods and Protocols (Vol. 115, pp. 141-148). Humana Press. https://doi.org/10.1385/1 - 59259-213-9:141.es_CO
dc.relation.referencesHengartner, MO. (2000). The biochemistry of apoptosis. Nature, 407(6805), 770-776. https://doi.org/10.1038/35037710.es_CO
dc.relation.referencesHingorani, R; Deng, J; Elia, J; McIntyre, C y Mittar, D. (2011). Detection of apoptosis using the BD annexin V FITC assay on the BD FACSVerseTM system. BD Biosciences, San Jose, 1-.es_CO
dc.relation.referencesHirsch, T; Marchetti, P; Susin, SA; Dallaporta, B; Zamzami, N; Marzo, I; Geuskens, M y Kroemer, G. (1997). The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene, 15(13), 1573-1581. https://doi.org/10.1038/sj.onc.1201324.es_CO
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