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    dc.contributor.authorLeal Parada, Edwar Armando.-
    dc.date.accessioned2024-07-02T19:30:09Z-
    dc.date.available2022-09-01-
    dc.date.available2024-07-02T19:30:09Z-
    dc.date.issued2022-
    dc.identifier.citationLeal Parada, E. A. (2022). Mecanismos inmunológicos en Cnidaria: Caracterización in silico de Péptidos antimicrobianos [Trabajo de Grado Pregrado, Universidad de Pamplona]. Repositorio Hulago Universidad de Pamplona. http://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/8917es_CO
    dc.identifier.urihttp://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/8917-
    dc.descriptionLos cnidarios son un grupo de invertebrados que surgieron hace 700 millones de años atrás. Presentan una gran complejidad que se ve reflejada en el genoma del sistema inmune. La caracterización de estos mecanismos de defensa ha sido posible gracias a los análisis genómicos y transcriptómicos llevados a cabo en diferentes cnidarios, los cuales han mostrado la presencia de varios genes que codifican moléculas de respuesta inmune conservadas en vertebrados. Para Cnidaria se han descrito diversos receptores de reconocimiento de patógenos (PRR), y moléculas de señalización intracelular que tienen como fin hacer efectiva la transcripción de genes con funciones inmunes, y moléculas efectoras, cuyo objetivo es la eliminación del patógeno. Los péptidos antimicrobianos favorecen la respuesta efectora contra patógenos y son moléculas claves dada su capacidad de acción contra hongos, virus y bacterias. Además, son altamente conservados y en Cnidaria tienen capacidad bactericida, lo cual los convierte en moléculas que pueden ser modelos para estudios evolutivos y de bioprospección. El objetivo de esta investigación fue caracterizar estructuralmente péptidos antimicrobianos (AMP) pertenecientes a la familia de las defensinas en diferentes especies de cnidarios mediante análisis computacional. Para alcanzar este propósito se llevó a cabo una búsqueda exhaustiva de secuencias homólogas a péptidos antimicrobianos pertenecientes a la familia de las defensinas en los proteomas disponibles para cnidarios, también se realizó un modelamiento 3D por homología de secuencias y una caracterización funcional de los péptidos con una herramienta desarrollada bajo un enfoque de aprendizaje automático. El modelamiento 3D por homología permitió la caracterización estructural de doce péptidos en 11 especies de cnidarios, los cuales mostraron similitud estructural con defensinas descritas en las especies Nasonia vitripennis, Pisum sativum, Solanum lycopersicum y Aurelia aurita. A estos péptidos también se les realizo una evaluación de diferentes propiedades fisicoquímicas como momento hidrofóbico, hidrofobicidad, carga neta, índice de anfifilia y punto isoeléctrico, mostrando valores que son ideales para AMP. La caracterización funcional mostro potencial bactericida de 20 péptidos contra las bacterias multirresistentes Escherichia coli, Pseudomonas aeruginosa y Klebsiella pneumoniae. Por último, se llevó a cabo la construcción de un árbol filogenético, donde se evidencia que la defensina Nuetrophil, descrita en Homo sapiens, comparte un ancestro común cercano con diferentes péptidos descritos en cnidarios, caracterizados por mostrar un potencial bactericida y una estructura α hélice rica en cisteínas (seis), típica de defensinas de mamíferos e insectos. Los resultados obtenidos muestran que Cnidaria presenta AMP con características estructurales y fisicoquímicas similares a las descritas en defensinas de insectos, mamíferos y plantas. Las características estructurales de estos péptidos, sus propiedades fisicoquímicas y su potencial funcional los perfila como moléculas prometedoras para hallazgo de nuevos antibióticos.es_CO
    dc.description.abstractCnidarians are invertebrates that emerged 700 million years ago. They present a great complexity that is reflected in the genome of the immune system. The characterization of these defense mechanisms in Cnidarians has been possible thanks to genomic and transcriptomic analyses, which have shown the presence of several genes that encode immune response molecules conserved in vertebrates. For Cnidaria, various pathogen recognition receptors (PRR) have been described, signaling molecules that have the purpose of making the transcription of genes with immune functions effective, and effector molecules, whose objective is the elimination of the pathogen. Antimicrobial peptides favor the effector response against pathogens and are key molecules given their ability to act against fungi, viruses and bacteria. In addition, they are highly conserved and in Cnidaria they have bactericidal capacity, which makes them molecules that can be models for evolutionary and bioprospecting studies. The objective of this research was to structurally characterize antimicrobial peptides (AMP) belonging to the defensin family in different species of Cnidarians by computational analysis. To achieve this purpose, an exhaustive search was carried out for sequences homologous to antimicrobial peptides belonging to the defensin family in the proteomes available for Cnidarians, as well as 3D modeling by sequence homology and a functional characterization of the peptides with a tool developed under a machine learning approach. 3D homology modeling allowed the structural characterization of twelve peptides in 11 Cnidarian species, which showed structural similarity with defensins described in the species Nasonia vitripennis, Pisum sativum, Solanum lycopersicum and Aurelia aurita. These peptides were also evaluated for different physicochemical properties such as hydrophobic moment, hydrophobicity, net charge, amphiphilic index and isoelectric point, showing values that are ideal for AMP. The functional characterization showed bactericidal potential of 20 peptides against multiresistant bacteria Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Finally, the construction of a phylogenetic tree was carried out, where it is evident that the Nuetrophil defensin, described in Homo sapiens, shares a close common ancestor with different peptides described in Cnidarians, characterized by showing a bactericidal potential and an α helix structure rich in cysteines (six), typical of mammalian and insect defensins. The results obtained show that Cnidaria present AMP with structural and physicochemical characteristics similar to those described in defensins of insects, mammals and plants. The structural characteristics of these peptides, their physicochemical properties and their functional potential outline them as promising molecules for the discovery of new antibiotics.es_CO
    dc.format.extent67es_CO
    dc.format.mimetypeapplication/pdfes_CO
    dc.language.isoeses_CO
    dc.publisherUniversidad de Pamplona - Facultad de Ciencias Básicas.es_CO
    dc.subjectCnidaria.es_CO
    dc.subjectPéptidos antimicrobianos.es_CO
    dc.subjectDefensinas.es_CO
    dc.subjectPropiedades fisicoquímicas.es_CO
    dc.subjectPotencial de acción.es_CO
    dc.titleMecanismos inmunológicos en Cnidaria: Caracterización in silico de Péptidos antimicrobianos.es_CO
    dc.typehttp://purl.org/coar/resource_type/c_7a1fes_CO
    dc.date.accepted2022-06-01-
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    dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2es_CO
    dc.type.coarversionhttp://purl.org/coar/resource_type/c_2df8fbb1es_CO
    Aparece en las colecciones: Biología

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