Adenoma de células hepatoides.

Abstract

Electrochemotherapy (ECT) is an antitumor therapeutic technique that consists of the generation of electrical pulses (direct current) locally in the tumor growth, which produce the opening of pores in the membrane of the electroporated tumor cells, favoring the entry of agents. chemotherapeutics that seek to cause the death of malignant cells through necrosis or apoptosis, during the process of cell division. The most commonly used chemotherapeutic agent in ECT is bleomycin. This medication has high intrinsic toxicity. It is a non-permeable molecule which under normal conditions cannot cross the cell membrane due to its size and physical-chemical properties. The circumanal hepatoid cell adenoma located in the perineal region is one of the benign neoplasms with the greatest presentation in non-neutered male canines, because the hepatoid cells have androgen receptors which are stimulated by testicular testosterone. A clinical case is presented of a 10-year-old entire male canine of the husky breed, with a history of excessive licking of the perineal area and bad odor. The owners noticed a week before arriving for consultation that some growths appeared around the anus and that they were ulcerated. The clinical examination revealed that the animal was alert, with a body condition of 3/5, body temperature of 39.9 °C, HR 100 bpm, normal heart and respiratory sounds, pink mucous membranes, TLLC 2 seconds, strong pulse. Paraclinical tests were performed to stage the patient and confirm possible diagnoses such as: blood count, renal and hepatic biochemistry, cytology, ultrasound, radiography and histopathology. Sample collection for cytological study was performed by fine needle puncture, showing cells similar to hepatocytes orienting towards the diagnosis: hepatoid cell adenoma, hepatoid cell adenocarcinoma, hepatoid cell epithelioma and apocrine carcinoma of the anal sacs, which was confirmed by histopathology hepatoid cell adenoma. Orchiectomy, mass removal and ECT were performed as a therapeutic plan with a favorable outcome.