• Repositorio Institucional Universidad de Pamplona
  • Tesis de maestría y doctorado
  • Facultad de Ciencias Básicas
  • Maestría en Biología Molecular y Biotecnología
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    dc.contributor.authorParada Botia, Mayra Yurley.-
    dc.date.accessioned2025-04-24T18:24:07Z-
    dc.date.available2022-
    dc.date.available2025-04-24T18:24:07Z-
    dc.date.issued2022-
    dc.identifier.citationParada Botia, M. Y. (2022). Efecto Apoptótico y/o Necrótico de Zearalenona en células humanas y su cuantificación en el arroz cultivado en Norte de Santander [Trabajo de Grado Maestría, Universidad de Pamplona]. Repositorio Hulago Universidad de Pamplona. http://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/9435es_CO
    dc.identifier.urihttp://repositoriodspace.unipamplona.edu.co/jspui/handle/20.500.12744/9435-
    dc.descriptionLas micotoxinas son metabolitos secundarios, sintetizados por diferentes especies de hongos filamentosos, siendo los géneros Fusarium, Aspergillus y Penicillium, los contaminantes micotoxigénicos más relevantes. Se encuentran frecuentemente como contaminantes naturales en una amplia variedad de alimentos (leche, frutos secos, granos, cereales y derivados) y piensos, representando un riesgo para la salud humana y animal. Por lo tanto, en el presente estudio se cuantificó y se estableció la presencia de ZEA en 3 muestras de arroz de cultivo (M009: 98 µg/Kg, M010:167 µg/Kg y M011: 490 µg/Kg) de 4 municipios de Norte de Santander por cromatografía líquida de alta eficacia (HPLC); a su vez, se pudo establecer la presencia de Fusarium sp., presuntivamente, teniendo en cuenta la caracterización fenotípica de acuerdo a la morfología macroscópica, microscópica y crecimiento micelial, en tres medios de cultivo (PDA, Avena, DG18). Adicionalmente, se evaluó el efecto citotóxico de un patrón de ZEA (10 µg/ml), mediante el ensayo de viabilidad (MTT), y la inducción de cambios morfológicos por microscopia electrónica de trasmisión (MET) en la línea celular HepG2. Los resultados obtenidos indicaron, que ZEA causó una disminución de la actividad metabólica, una reducción significativa en los porcentajes de proliferación celular (p<0,0001), de manera dependiente de la concentración y el tiempo de exposición; y la inducción de cambios morfológicos característicos de la muerte celular por apoptosis. Por citometría de flujo se evaluaron los cambios bioquímicos como externalización de la fosfatidilserina, fragmentación del ADN y pérdida del potencial de membrana mitocondrial, en células polimorfonucleares (PMN). Los resultados indicaron que ZEA, desencadena una serie de eventos de muerte celular, característicos del proceso apoptótico.es_CO
    dc.description.abstractMycotoxins are secondary metabolites, synthesized by different species of filamentous fungi, the genera Fusarium, Aspergillus and Penicillium, are the most relevant mycotoxigenic contaminants. They are frequently found as natural contaminants in a wide variety of foods (milk, nuts, grains, cereals and derivatives) and feed, representing a risk to human and animal health. Therefore, in the present study, the presence of ZEA was quantified and established in 3 cultivated rice samples (M009: 98 µg/Kg, M010: 167 µg/Kg and M011: 490 µg/Kg) from 4 municipalities of Norte de Santander by high performance liquid chromatography (HPLC); in turn, the presence of Fusarium sp. could be established, presumptively, taking into account the phenotypic characterization according to macroscopic and microscopic morphology and mycelial growth, in three culture media (PDA, Oatmeal Agar, DG18). Additionally, the cytotoxic effect of a ZEA pattern (10 µg/ml) was evaluated by means of the viability assay (MTT), and the induction of morphological changes by transmission electron microscopy (TEM) in the HepG2 cell line. The results obtained indicated that ZEA caused a decrease in metabolic activity, a significant reduction in the percentages of cell proliferation (p<0.0001), depending on the concentration and exposure time; and the induction of morphological changes characteristic of cell death by apoptosis. Biochemical changes such as externalization of phosphatidylserine, DNA fragmentation and loss of mitochondrial membrane potential in polymorphonuclear cells (PMN) were evaluated by flow cytometry. The results indicated that ZEA triggers a series of cell death events, characteristic of the apoptotic process.es_CO
    dc.format.extent140es_CO
    dc.format.mimetypeapplication/pdfes_CO
    dc.language.isoeses_CO
    dc.publisherUniversidad de Pamplona – Facultad de Ciencias Básicas.es_CO
    dc.subjectArroz.es_CO
    dc.subjectCitotoxicidad.es_CO
    dc.subjectFusarium.es_CO
    dc.subjectMuerte celular.es_CO
    dc.subjectZearalenona.es_CO
    dc.titleEfecto Apoptótico y/o Necrótico de Zearalenona en células humanas y su cuantificación en el arroz cultivado en Norte de Santander.es_CO
    dc.typehttp://purl.org/coar/resource_type/c_bdcces_CO
    dc.date.accepted2022-
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